{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:15:29Z","timestamp":1785546929575,"version":"3.56.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah311142-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Left ventricular mechanical dispersion (LV\u2010MD), an indicator of LV dyssynchrony, is not well studied in heart failure with reduced ejection fraction (HFrEF). This study aims to investigate the profile of LV\u2010MD in HFrEF, and evaluate whether it provides predictive information in terms of LV reverse remodeling (LVRR), particularly, on top of LV global longitudinal strain (LV\u2010GLS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311142-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this observational cohort study, 239 consecutive patients hospitalized for HFrEF from 2020 to 2022 were included, and baseline and follow\u2010up echocardiographic studies were performed. By strain analysis, LV\u2010MD was calculated as the SD of time to peak negative longitudinal strain from 17 LV segments. LVRR was defined as an increase in LVEF of \u226510% and a decrease in LV end\u2010diastolic diameter index of \u226510% or \u226433\u2009mm\/m\n              <jats:sup>2<\/jats:sup>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311142-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">During a median follow\u2010up of 19\u2009months, LVRR occurred in 152 patients (64%). A great heterogeneity of LV\u2010MD ranging from 30 to 202\u2009milliseconds was present in the cohort and 94 (84%) in 112 patients who were with LV\u2010MD &gt;76\u2009milliseconds had no left bundle\u2010branch block. LV\u2010MD \u226476\u2009milliseconds independently predicted LVRR and possessed greater discriminatory ability than LV\u2010GLS by receiver operating characteristics analysis. Moreover, addition of LV\u2010MD \u226476\u2009milliseconds and LV\u2010GLS \u2264\u22125.5% to a multivariable model, including age, HF duration, systolic blood pressure, QRS duration and use of angiotensin receptor\u2010neprilysin inhibitors, improved predictive performance in terms of LVRR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311142-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">LV mechanical dyssynchrony is widely present in HFrEF, irrespective of left bundle\u2010branch block. LV\u2010MD is significantly associated with LVRR, independent of and superior to LV\u2010GLS. Combined assessments of LV\u2010MD and LV\u2010GLS provide additive value beyond clinical variables for predicting LVRR in HFrEF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040652","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:10:48Z","timestamp":1751591448000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Left Ventricular Mechanical Dispersion and Its Value in Combination With Global Longitudinal Strain to Predict Reverse Remodeling in Patients With Heart Failure With Reduced Ejection Fraction"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9121-1185","authenticated-orcid":false,"given":"Fuyang","family":"Liu","sequence":"first","affiliation":[{"name":"Huazhong University of Science and Technology","place":["Wuhan, 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Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-4798","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology","place":["Wuhan, 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