{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:48:01Z","timestamp":1786661281586,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah310927-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Longer\u2010term morbidity post septal myectomy (SM) in obstructive hypertrophic cardiomyopathy has not been well characterized at a national level. We aimed to investigate the nonfatal longer\u2010term post\u2010SM outcomes from a national all\u2010payer individual\u2010level claims.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310927-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">The Symphony Health Claims database (2016\u20132021) was analyzed to identify all adult patients with obstructive hypertrophic cardiomyopathy who underwent SM in the United States and had at least 1 claim within 120\u2009days before SM. The primary outcome was cardiovascular hospitalizations (CVH) starting &gt;30\u2009days post\u2010SM.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310927-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 5324 patient (median age 62.0 [52.0\u201370.0], 53.2% female, 70% commercial insurance) underwent SM and 95.8% were followed &gt;30\u2009days post SM. During 2.7 (1.2\u20134.2) years median follow\u2010up, CVH occurred in 46.7% (80% of CVH within 16\u2009months of SM). CVH for new atrial fibrillation\/flutter was 25.4%, ventricular arrhythmias 9.7%, syncope 9.3%, myocardial infarction 5.2%, cardiac arrest 1.6%, ventricular septal defect 0.9%, and need for advanced heart failure therapy 0.6%. Repeat SM was required in 43 patients (0.8%). The strongest predictors of CVH post SM were presence of an implantable cardioverter\u2010defibrillator at baseline (adjusted odds ratio [aOR], 1.72 [95% CI, 1.50\u20131.97],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001), chronic obstructive pulmonary disease (aOR, 1.65 [95% CI, 1.44\u20131.89],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001), and chronic kidney disease (aOR, 1.45 [95% CI, 1.26\u20131.66],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310927-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Over a 3\u2010year period, SM for obstructive hypertrophic cardiomyopathy was associated with a high burden of CVH. Investigating the drivers of these events and strategies to mitigate the high incidence of intermediate and long\u2010term nonfatal complications post SM will help improve the care of patients with obstructive hypertrophic cardiomyopathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040655","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T10:23:15Z","timestamp":1752488595000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular Hospitalizations Burden Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"14","author":[{"given":"Ahmed","family":"Altibi","sequence":"first","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University","place":["Portland, USA"]},{"name":"Yale University School of Medicine","place":["New Haven, 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USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-006X","authenticated-orcid":false,"given":"Howard","family":"Song","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-6526","authenticated-orcid":false,"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University","place":["Portland, 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