{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:25Z","timestamp":1789013305239,"version":"build-2803163510"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stent thrombosis is a serious complication of angioplasty with stenting, as evidenced by the associated morbidity and mortality events. Its incidence is particularly elevated after emergent carotid stenting in patients with acute ischemic stroke, reaching 20%. A better understanding of the mechanisms driving stent thrombosis will open up new avenues to limit this alarming complication. Its 2 main determinants are the ruptured atherosclerotic plaque and the stent itself, whose particular role in the process remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using a new macrofluidic model mimicking the geometry of the human carotid artery, the intrinsic thrombogenicity of carotid stents was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Real\u2010time video microscopy combined with scanning electron microscopy revealed that the Casper and the Wallstent, 2 widely used commercial stents, are thrombogenic and promote the formation of a massive thrombus in the carotid bifurcation (Casper: median, 9 [interquartile range, 6.4\u201324.4]\u00d710\n                      <jats:sup>5<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ; Wallstent: median, 9.5 [interquartile range, 1.5\u201320.8]\u00d710\n                      <jats:sup>5<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ). This result was consistent with a retrospective clinical study in stented patients with tandem lesions, in which 21.1% presented stent thrombosis, and 38.7% of these cases occurred at the bifurcation. Moreover, a stent lying in the carotid bifurcation of the macrofluidic model generated a prothrombotic high\u2010shear environment, triggering thrombosis, which was prevented in the presence of aspirin or abciximab. Finally, stents with a new design could avoid the formation of large thrombi in the carotid bifurcation (full stent: median, 8.9 [interquartile range, 7.8\u201317.2]\u00d710\n                      <jats:sup>5<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ; stent with an opening at the bifurcation: median, 2.1 [interquartile range, 1.1\u20133]\u00d710\n                      <jats:sup>5<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ), opening up the perspective of new ways to prevent carotid stent thrombosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stents placed inside the carotid bifurcation are responsible for a massive thrombus formation that could lead to stent thrombosis. The absence of mesh prevents its formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040671","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:15:22Z","timestamp":1785496522000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Shear Environment Promotes Acute Carotid Stent Thrombosis in Patients With Tandem Lesions"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2044-9571","authenticated-orcid":false,"given":"Axelle Y.","family":"Kern","sequence":"first","affiliation":[{"name":"University of Strasbourg, INSERM, EFS Grand\u2010Est, BPPS UMR_S1255, FMTS","place":["Strasbourg, 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