{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:24:15Z","timestamp":1754162655333,"version":"3.41.2"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Background<\/jats:title>\n Spontaneous hemoptysis is a well\u2010recognized risk of palliated single ventricle circulation, yet published literature is limited to case reports and small case series. In this study, we sought to determine the long\u2010term prevalence of spontaneous hemoptysis among patients with palliated single ventricle circulation at a single institution. Secondarily, we sought to characterize the clinical outcomes after spontaneous hemoptysis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective study of patients with a history of Glenn or Fontan palliation seen from January 1, 1990 to January 21, 2023. Episodes of spontaneous hemoptysis were identified through 2 independent database screens that queried\n International Classification of Diseases, Ninth Revision<\/jats:italic>\n (\n ICD\u20109<\/jats:italic>\n ) and\n Tenth Revision<\/jats:italic>\n (\n ICD\u201010<\/jats:italic>\n ) codes and electronic medical records for \u201cpulmonary hemorrhage\u201d and \u201chemoptysis.\u201d Positive screens were subsequently confirmed or reclassified by manual chart review.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 799 patients with palliated single ventricle circulation, 10.9% (87\/799) screened positive for hemoptysis. Following verification with manual chart review, 3.4% (27\/799) of patients with palliated single ventricle circulation had spontaneous hemoptysis. A total of 61 episodes of spontaneous hemoptysis occurred in 27 patients. Of all hemoptysis episodes, 83.6% (51\/61) occurred after Fontan palliation. Of patients with hemoptysis, 51.9% (14\/27) had multiple episodes of hemoptysis with recurrence at a median of 0.6\u2009years (range 1\u2009day\u20138.5\u2009years) after the first episode.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n To our knowledge, this is the first study that quantifies prevalence of hemoptysis in a large cohort of patients with palliated single ventricle circulation. Overall, prevalence of spontaneous hemoptysis was low (3.4%) among patients with palliated single ventricle circulation and there was a moderate rate of recurrence (51.9%).<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.040713","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:02:27Z","timestamp":1750723347000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Thirty\u2010Year Prevalence of Spontaneous Hemoptysis in Palliated Single Ventricle Circulation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-5491","authenticated-orcid":false,"given":"Anna K.","family":"Dibbs","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin, Children\u2019s Wisconsin, Herma Heart Institute","place":["Milwaukee, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-3170","authenticated-orcid":false,"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin","place":["Milwaukee, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy Y.","family":"Pan","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin","place":["Milwaukee, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-5258","authenticated-orcid":false,"given":"Andrew D.","family":"Spearman","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Children\u2019s Wisconsin, Herma Heart Institute","place":["Milwaukee, USA"]},{"name":"Cardiovascular Research Center, Medical College of Wisconsin","place":["Milwaukee, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9090309"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(01)02813-2"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e318280d564"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01482.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.08.026"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311764"},{"key":"e_1_3_1_8_2","first-page":"139","article-title":"Images in cardiovascular medicine. Life\u2010threatening hemoptysis after the Fontan procedure","volume":"4","author":"Santoro G","year":"2003","unstructured":"Santoro G, Carrozza M, Cappelli Bigazzi M, Morelli C, Sessa F, Calabr\u00f2 R. Images in cardiovascular medicine. Life\u2010threatening hemoptysis after the Fontan procedure. Ital Heart J. 2003;4:139\u2013141.","journal-title":"Ital Heart J"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(08)70572-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.03.022"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23497"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.3.e7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400104"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.11.007"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.02.003"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.11.040"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.834192"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-024-06002-7"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.040713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:58:08Z","timestamp":1753876688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.040713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":17,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1161\/JAHA.124.040713"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.040713","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040713"}}