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The presence of metabolic dysfunction\u2010associated fatty liver disease not only exacerbates insulin resistance and metabolic imbalance but also contributes to the progression of myocardial infarction in a multifaceted and multifaceted manner through interactions with peripheral adipose tissue, the intestinal microbiota, and epigenetic alterations, as well as \u201cdirect communication\u201d between the heart and the liver. Both physiologically and pathologically, it is of interest to note that cross\u2010organ \u201cdirect communication\u201d between the heart and the liver can occur in a variety of ways through a variety of means, including extracellular vesicles. In recent years, a variety of drugs with cardiovascular benefits have been found to treat metabolic dysfunction\u2010associated fatty liver disease, and the mechanisms are worth exploring. It is important to explore the hepatic mechanism of myocardial infarction from a new perspective of metabolic dysfunction\u2010associated fatty liver disease, which is centered on the imbalance of metabolic homeostasis and the process of heart\u2013hepatic interorgan communication, for the prevention and treatment of cardiovascular diseases.<\/jats:p>","DOI":"10.1161\/jaha.124.040775","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:08:23Z","timestamp":1756465703000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Hepatic Mechanisms of Myocardial Infarction: A New Perspective in Metabolic Dysfunction\u2010Associated Fatty Liver Disease"],"prefix":"10.1161","volume":"14","author":[{"given":"Jing","family":"Cui","sequence":"first","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-2540","authenticated-orcid":false,"given":"Yiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]},{"name":"China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-863X","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.01.030"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31150"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102938"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0941"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310779111"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.11.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000001183"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.07.035"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(21)00020-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac783"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.062"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-020-00419-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11030155"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade4110"},{"key":"e_1_3_2_19_2","first-page":"1308","article-title":"Fibroblast growth factor 21 attenuates inflammation and oxidative stress in atherosclerotic rat via enhancing the Nrf1\u2010ARE signaling pathway","volume":"11","author":"Jia H","year":"2018","unstructured":"Jia H, Cheng J, Zhou Q, Peng J, Pan Y, Han H. 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