{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:53:29Z","timestamp":1787165609221,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">First cardiometabolic disorders (FCMDs) and dementia pose a significant burden on aging populations. Investigating the association between atmospheric pollutants and the progression of FCMDs and dementia is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A prospective analysis was conducted on 413\u2009149 participants from the UK Biobank. Atmospheric pollutant concentrations were calculated using land\u2010use regression models. We used a multistate model and calculated the polygenic risk score for dementia to analyze the associations of pollutants on the relevant trajectories from baseline to FCMD, subsequent dementia, and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Over 13\u2009years, 65\u2009336 patients with FCMD were identified, with 2584 developing dementia and 10\u2009664 dying. Each interquartile range increase in pollutant concentrations showed the hazard ratios (HRs) of particulate matter with aerodynamic diameter \u22642.5 \u03bcm (HR, 1.03 [95% CI, 1.02\u20131.05]); nitrogen dioxide (HR, 1.04 [95% CI, 1.03\u20131.05]), and nitrogen oxides (HR, 1.03 [95% CI, 1.02\u20131.04]) for transitioning from baseline to FCMD; particulate matter with aerodynamic diameter \u22642.5 \u03bcm (HR, 1.11 [95% CI, 1.05\u20131.16]; nitrogen dioxide: HR, 1.12 [95% CI, 1.06\u20131.18]; and nitrogen oxides (HR, 1.07 [95% CI, 1.03\u20131.12]) for transitioning from FCMD to dementia, and the association between pollutants and this trajectory remained consistent after adjusting for genetic susceptibility to dementia (particulate matter with aerodynamic diameter \u22642.5 \u03bcm: HR, 1.06 [95% CI, 1.04\u20131.08]; nitrogen dioxide: HR, 1.05 ([95% CI, 1.03\u20131.07); and nitrogen oxides: HR, 1.05 [95% CI, 1.03\u20131.06]) for transitioning from baseline to death; and particulate matter with aerodynamic diameter \u22642.5 \u03bcm: HR, 1.03 ([95% CI, 1.00\u20131.05); nitrogen dioxide: HR, 1.05 ([95% CI, 1.02\u20131.08); nitrogen oxides: HR, 1.04 ([95% CI, 1.01\u20131.06]) for transitioning from subsequent FCMD to death. Particulate matter with aerodynamic diameter \u226410 \u03bcm was only significantly associated with the transition from baseline to FCMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our study provides the first evidence that atmospheric pollutants are associated with the progression of FCMD and subsequent dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040844","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:05:14Z","timestamp":1746173114000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13\u2010Year Longitudinal 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