{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:37:29Z","timestamp":1793263049726,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:sec id=\"jah310959-sec-0001\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The role of iron deficiency (ID) in ST\u2010segment\u2013elevation myocardial infarction (STEMI) remains unclear. This study aimed to assess whether ID is associated with impaired myocardial reperfusion in STEMI and whether this association is affected by ID definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah310959-sec-0002\" xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included 942 consecutive patients with STEMI successfully treated with primary percutaneous coronary intervention. ID was defined either as recommended by international guidelines or, alternatively, as ferritin &lt;100\u2009ng\/mL, transferrin saturation &lt;20%, or serum iron \u226413\u2009\u03bcmol\/L. In 595 patients, serum soluble transferrin receptor levels were measured. Impaired myocardial reperfusion was defined as lack of ST\u2010segment resolution \u226550% 60 to 90\u2009minutes after percutaneous coronary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah310959-sec-0003\" xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      ID prevalence varied across these definitions. Impaired reperfusion was present in 12.7% of patients without ID and 41.0% of those with ID defined by transferrin saturation &lt;20% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). This association was less pronounced for serum iron \u226413\u2009\u03bcmol\/L, weaker for guideline criteria, and absent for high (\u22651.59\u2009mg\/L) soluble transferrin receptor levels or low ferritin. Transferrin saturation &lt;20%, but not ferritin\u2010based criteria, was associated with poorer clinical course and left ventricular function and higher in\u2010hospital mortality and remained an independent predictor of impaired reperfusion after adjusting for baseline predictors and anemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah310959-sec-0004\" xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">ID defined by transferrin saturation &lt;20% is strongly related to impaired ST resolution and predicts a worse in\u2010hospital outcome in patients with STEMI treated with primary percutaneous coronary intervention. The association of other ID criteria with myocardial reperfusion or with the clinical course is weaker or absent. The potential preventive or therapeutic strategies targeting ID in STEMI warrant further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040845","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T06:39:36Z","timestamp":1747895976000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Iron Deficiency Is Associated With Impaired Myocardial Reperfusion in ST\u2010Segment\u2013Elevation Myocardial Infarction: Influence of the Definition Used"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-6277","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Barrab\u00e9s","sequence":"first","affiliation":[{"name":"Vall d\u2019Hebron University Hospital and Research Institute (VHIR)","place":["Barcelona, Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Bellaterra, Spain"]},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Cardiovasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-5010","authenticated-orcid":false,"given":"Javier","family":"Inserte","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital and Research Institute (VHIR)","place":["Barcelona, Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Bellaterra, Spain"]},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Cardiovasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Castellote","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital","place":["Barcelona, 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