{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:24:11Z","timestamp":1789932251487,"version":"4.0.1"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data on long\u2010term prognostic factors in patients with cancer\u2010related stroke are limited. The purpose of this study was to evaluate long\u2010term outcomes and investigate prognostic factors of cancer\u2010related stroke using a linked data set.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Between January 2008 and December 2014, patients with cancer\u2010related stroke (n=690) were included in a linked data set comprising the Health Insurance Review and Assessment Service claims database and the Clinical Research Center for Stroke registry data. Outcomes were long\u2010term mortality, major bleeding including intracerebral hemorrhage and gastrointestinal bleeding, and recurrent ischemic stroke after ischemic stroke. Clinical factors related to outcomes after ischemic stroke, including vascular risk factors, acute stroke management, and types of cancer, were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Of the 690 patients with cancer\u2010related stroke (mean age, 68.5\u2009years and 61.7% male) during a median 1.7 year period, 401 (58.1%) patients died during follow\u2010up duration. Multivariate Cox regression analysis revealed that old age (hazard ratio [HR], 1.30 per 10\u2009years [95% CI, 1.17\u20131.45]), stroke severity (HR, 1.05 [95% CI, 1.03\u20131.06]), anticoagulation at discharge (HR, 1.67 [95% CI, 1.02\u20132.74]), and types of cancer, such as pancreatic (HR, 3.73 [95% CI, 2.70\u20135.16]), hepatobiliary (HR, 2.31 [95% CI, 1.78\u20133.00]), and lung cancers (HR, 1.73 [95% CI, 1.33\u20132.25]), were significantly associated with long\u2010term mortality. Major bleeding occurred in 42 patients (6.1%), and recurrent ischemic stroke was observed in 89 patients (12.9%) during the follow\u2010up period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Long\u2010term outcomes of cancer\u2010related stroke are poor. Treatment at discharge and cancer type are crucial factors associated with long\u2010term mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040883","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:51:14Z","timestamp":1754477474000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010Term Outcomes and Predictors in Cancer\u2010Related Stroke Using the Linked Data Set"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-5627","authenticated-orcid":false,"given":"Tae Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seoul, Korea"]},{"name":"Seoul National University Hospital","place":["Seoul, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-3462","authenticated-orcid":false,"given":"Ji 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