{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:51Z","timestamp":1782992751213,"version":"3.54.5"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In the assessment of coronary physiology, non\u2010hyperemic pressure ratios (NHPRs) provide an alternative to fractional flow reserve (FFR) without the need for hyperemic agents, reducing procedural time, side effects, and costs. However, it remains unclear whether NHPRs have similar diagnostic performance in the different coronary arteries. This study evaluates the diagnostic performance of NHPRs compared with FFR, stratified by coronary artery, in stable patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a systematic review and individual patient\u2010level data meta\u2010analysis from prospective studies involving patients with intermediate to severe coronary stenosis who underwent physiological assessment with NHPRs and FFR. NHPRs included resting full\u2010cycle ratio or instantaneous wave\u2010free ratio (iFR). The diagnostic performance of NHPRs was calculated using a threshold of \u22640.89 for NHPRs with FFR \u22640.80 as the reference and by stratifying between the left anterior descending artery (LAD) and non\u2010LAD vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 2120 paired FFR and NHPRs (1257 resting full\u2010cycle ratio, 863 iFR) measurements were analyzed. The LAD artery was the interrogated vessel in 67% of cases, the left circumflex artery in 15%, and the right coronary artery in 17%. The mean NHPR and FFR values were 0.80\u00b10.17 and 0.71\u00b10.14, respectively. The overall sensitivity, specificity, and accuracy of NHPRs were 82%, 86%, and 83%. In non\u2010LAD vessels, NHPRs had significantly lower sensitivity and accuracy, but higher specificity compared with LAD (69% versus 87%, 76% versus 86%, and 91% versus 81%, respectively,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001 for all). The optimal NHPRs cutoff for detecting significant lesions differed between LAD (\u22640.88) and non\u2010LAD (\u22640.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">NHPRs demonstrated\u00a0lower diagnostic performance in non\u2010LAD vessels compared with the LAD. These results underscore the need for vessel\u2010specific interpretation of\u00a0NHPR measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040916","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:03:36Z","timestamp":1768827816000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Performance of Non\u2010Hyperemic Pressure Ratios Versus Fractional Flow Reserve Stratified by Coronary Artery: A\u00a0Systematic Review and Meta\u2010Analysis of Individual Patient\u00a0Data"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-2012","authenticated-orcid":false,"given":"Tatyana","family":"Storozhenko","sequence":"first","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]},{"name":"L.T. 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