{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:13Z","timestamp":1787018113088,"version":"build-2736575974"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Low fruit intake is a global risk factor for cardiometabolic diseases. This study sought to investigate vascular and metabolic effects of increasing total and select fruit intake in adults with prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This randomized, 2\u2010arm parallel, partially controlled feeding study provided participants (n=82, aged 45\u00b115\u2009years, 30\u00b16\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) weekly diets (1500 [women] or 1750\u2009kcal\/d [men]) incorporating 1 avocado and 1 cup of mango (avocado\u2013mango diet) daily for 8\u2009weeks or energy\u2010matched low\u2010fat, low\u2010fiber foods (control diet). Flow\u2010mediated vasodilation was the primary end point. Central and brachial blood pressure; pulse\u2010wave velocity; metabolic, inflammatory, and kidney function markers; and dietary intake were secondary end points. Change (\u0394) data were analyzed by mixed model ANCOVA or Wilcoxon rank\u2010sum test, and postprandial and dietary intake data by repeated\u2010measures ANOVA using SAS 9.4 (SAS Institute, Cary, NC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Changes in percentage of flow\u2010mediated vasodilation were significantly different between interventions (effect, \u22122.11\u00b10.77%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008), increasing \u22481% on the avocado\u2013mango diet and decreasing on the control diet, as were changes in central and brachial diastolic blood pressure (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.07 and\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03, respectively), specifically in men. Other end points were generally not different between diets (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &gt;0.05), although select lipids and kidney markers were marginally different (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.1). Total fruit, dietary fiber, vitamin C, and monounsaturated fat intake significantly increased during the avocado\u2013mango diet compared with the control diet (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In adults with prediabetes, daily inclusion of avocado and mango increases fruit consumption, diversifies nutrient composition, and improves vascular function associated with cardiovascular health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>REGISTRATION<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT05353790.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040933","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:10:31Z","timestamp":1771301431000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes"],"prefix":"10.1161","volume":"15","author":[{"given":"Chelsea","family":"Preiss","sequence":"first","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-2346","authenticated-orcid":false,"given":"Sameer","family":"Tunio","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-8574","authenticated-orcid":false,"given":"Lasantha Krishan","family":"Hirimuthugoda","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Zoltoski","sequence":"additional","affiliation":[{"name":"Illinois College of Optometry","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-1739","authenticated-orcid":false,"given":"Rachael L.","family":"Ellison","sequence":"additional","affiliation":[{"name":"Rosalind Franklin University of Medicine and Science","place":["North Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-4143","authenticated-orcid":false,"given":"Amandeep K.","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-4176","authenticated-orcid":false,"given":"Indika","family":"Edirisinghe","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-9852","authenticated-orcid":false,"given":"Britt M.","family":"Burton\u2010Freeman","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_3_2_3_2","unstructured":"Noncommunicable Diseases Rehabilitation and Disability (NCD) Surveillance Monitoring and Reporting (SMR) World Health Organization (WHO) . 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