{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:46:16Z","timestamp":1774266376237,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah311089-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Left atrial structural remodeling contributes to the persistence of atrial fibrillation (AF) and influences the outcomes of catheter ablation (CA). We investigated the usefulness of\n              <jats:sup>18<\/jats:sup>\n              F\u2010fluorodeoxyglucose\u2010positron emission tomography in detecting low atrial glucose uptake (LGU) as a potential marker of fibrosis and its predictive value for CA success in persistent AF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311089-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty\u2010six patients without diabetes with persistent AF scheduled for CA underwent nicotinic acid\u2010stimulated\n              <jats:sup>18<\/jats:sup>\n              F\u2010fluorodeoxyglucose\u2010positron emission tomography to assess global and segmental LGU before CA. LGU was compared with low voltage areas on electroanatomical mapping, left atrial volume index via echocardiography, and late gadolinium enhancement from cardiac magnetic resonance imaging as indicators of fibrosis. Patients were followed for up to 24\u2009months post CA to assess AF recurrence.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311089-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Global LGU extent was 16.8% (7.6\u201342.6) and correlated with left atrial volume index (R\n              <jats:sup>2<\/jats:sup>\n              =0.20,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.039) and low voltage area during AF and right atrial pacing (R\n              <jats:sup>2<\/jats:sup>\n              =0.54 and R\n              <jats:sup>2<\/jats:sup>\n              =0.35 respectively, both\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). Multivariable analysis showed that LGU significantly predicted moderate\/severe low voltage area remodeling (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001) with an area under the curve of 0.78 (95% CI, 0.58\u20130.97), independent of clinical and imaging parameters. AF recurred in 50% of patients. LGU &gt;17%, but not late gadolinium enhancement, predicted AF recurrence (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.026; AUC, 0.67 [95% CI, 0.48\u20130.86]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311089-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Nicotinic acid\u2010enhanced\n              <jats:sup>18<\/jats:sup>\n              F\u2010fluorodeoxyglucose\u2010positron emission tomography LGU extent reflects fibrosis by low voltage areas and predicts AF recurrence after CA in patients with persistent AF. This suggests that it could serve as a noninvasive tool for assessing atrial fibrosis and remodeling in atrial cardiomyopathy due to persistent AF.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.041491","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:03:34Z","timestamp":1751591014000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Left Atrial Remodeling Identification and Catheter Ablation Outcomes With\n            <sup>18<\/sup>\n            F\u2010Fluorodeoxyglucose Positron Emission Tomography in Persistent Atrial Fibrillation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2815-3097","authenticated-orcid":false,"given":"Tristan","family":"Raoult","sequence":"first","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-8558","authenticated-orcid":false,"given":"Bernhard L.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Garnir","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-8757","authenticated-orcid":false,"given":"Christophe","family":"Scav\u00e9e","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-1611","authenticated-orcid":false,"given":"Varnavas","family":"Varnavas","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lien","family":"Wauters","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Gruson","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires St. Luc, P\u00f4le de Recherche Cardiovasculaire (CARD)","place":["Brussels, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Nellessen","sequence":"additional","affiliation":[{"name":"Cliniques 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