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Cardiovascular effects triggered by air pollution were regarded as the dominant contributor to stroke pathogenesis, indicating the interconnected pathological basis of cardio\u2010cerebrovascular multimorbidity in driving acute cerebrovascular events. By adopting the adverse outcome pathway as a pivotal tool, this review summarized air pollution\u2013related effects on the cerebral blood flow into 3 aspects, namely, direct damage to the cerebrovascular system, systemic inflammation from the pulmonary to the cardiovascular system, and blood pressure changes mediated by the autonomic nervous system. After triggering molecular initiating events such as reactive oxygen species generation and sensory receptor activation, air pollutants may cause key events affecting the blood\u2013brain barrier integrity, thrombosis, atherosclerosis, and hypertension, eventually leading to acute cerebrovascular events. This review underscored the critical role of cardio\u2010cerebrovascular multimorbidity in air pollution\u2013related cerebrovascular disease, suggesting a complex interplay of mechanisms affecting brain health. 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