{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:25:33Z","timestamp":1790612733178,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah311132-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Offspring blood pressure (OBP) may be programmed during pregnancy. Accordingly, maternal third\u2010trimester 24\u2010hour urine aldosterone levels are associated with fetoplacental trophic effects. Furthermore, high potassium and low sodium intakes are generally recommended in adults with normal renal function. We hypothesized that maternal 24\u2010hour urine aldosterone levels were positively associated with OBP, and maternal intake of potassium and sodium may influence the association. The study aimed to investigate associations between maternal third\u2010trimester 24\u2010hour urine aldosterone, potassium and sodium intake, and OBP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311132-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">In the prospective OCC (Odense Child Cohort), 475 mother\u2013child dyads had 24\u2010hour urine aldosterone from gestational week 29 and OBP (systolic and diastolic), at ages 3 and 18 months and 3 and 5\u2009years. Maternal potassium and sodium intakes were calculated from 24\u2010hour urine potassium and urine sodium excretions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311132-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Increased maternal 24\u2010hour urine aldosterone associated with higher systolic blood pressure in offspring at ages 3 months (\u03b2=0.54\u2009mm\u2009Hg [95% CI, 0.29; 0.79]) and 18 months (\u03b2=0.24\u2009mm\u2009Hg [95% CI, 0.03; 0.44]). One thousand mg\/d increase in maternal potassium intake was associated with an average increase in offspring systolic blood pressure of 0.68\u2009mm\u2009Hg (95% CI, 0.02\u20131.34) up to age 5\u2009years (pooled), with significant associations only in girls (\u03b2=1.14\u2009mm\u2009Hg [95% CI, 0.21\u20132.08]). No significant association was seen between maternal sodium intake and OBP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311132-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Elevated maternal 24\u2010hour urine aldosterone and higher dietary potassium intake were associated with higher OBP but within normal range in young children, and girls were more susceptible to maternal potassium intake.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311132-sec-0005\" xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: ID NCT02183558.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.042165","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:10:00Z","timestamp":1751591400000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Diurnal Urinary Aldosterone Excretion and Potassium Intake During Pregnancy Are Associated With High Normal Blood Pressure in Early Childhood"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-3327","authenticated-orcid":false,"given":"Hajir","family":"Al\u2010Jorani","sequence":"first","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"Faculty of Health Sciences, University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-1680","authenticated-orcid":false,"given":"Richard Christian","family":"Jensen","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-5778","authenticated-orcid":false,"given":"Tina K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"University of Southern Denmark","place":["Odense, Denmark"]},{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-6853","authenticated-orcid":false,"given":"Henrik Thybo","family":"Christesen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Southern Denmark","place":["Odense, Denmark"]},{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-2535","authenticated-orcid":false,"given":"Jan Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-2270","authenticated-orcid":false,"given":"Lucas","family":"Bacmeister","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2013Bad Krozingen, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg","place":["Freiburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6636-3080","authenticated-orcid":false,"given":"Ralf","family":"Dechend","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between the Max\u2010Delbr\u00fcck\u2010Center for Molecular Medicine in the Helmholtz Association and the Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin","place":["Berlin, Germany"]},{"name":"HELIOS Clinic Berlin\u2010Buch, Department of Cardiology and Nephrology","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-8025","authenticated-orcid":false,"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-213X","authenticated-orcid":false,"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9504","authenticated-orcid":false,"given":"Marianne S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106356"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12924"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn763"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0525"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(02)00179-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1145-4"},{"key":"e_1_3_2_8_2","first-page":"61","article-title":"Mineralocorticoids in normal and hypertensive pregnancies","volume":"2","author":"Ehrlich EN","year":"1978","unstructured":"Ehrlich EN. 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