{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:06:59Z","timestamp":1790928419153,"version":"4.1.0"},"reference-count":144,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Chronic arterial hypertension causes cerebral microvascular dysfunction and increases dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease duration, the degree of irreversible tissue damage, and whether microvascular function can be restored. This study aimed to understand molecular and cellular temporospatial mechanisms of disease in the course of hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We investigated the effects of initial, early chronic and late chronic hypertension in the frontal brain of spontaneously hypertensive stroke\u2010prone rats by applying behavioral tests, histopathology, immunofluorescence, fluorescence\u2010activated cell sorting, microvascular\/neural tissue RNA sequencing, and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose positron emission tomography imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Chronic hypertension caused behavioral deficits associated with frontal cortex function. Our results highlight stage\u2010dependent responses to continuous microvascular stress and wounding by hypertension. Early chronic responses included a fast recruitment of activated microglia to the blood vessels, immigration of peripheral immune cells, blood\u2013brain barrier breakdown and an energy\u2010demanding hypermetabolic state. Vascular adaptation mechanisms were observed in later stages and included angiogenesis and upregulation of cellular adhesion molecules and extracellular matrix. Among the top upregulated genes in blood vessels, we identified\n                      <jats:italic toggle=\"no\">Igfbp\u20105<\/jats:italic>\n                      , which attenuates protective insulin\u2010like growth factor 1 signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our study provides new insight into mechanisms underlying hypertensive pathobiology and highlights its stage\u2010dependent nature. This groundwork will be helpful for basic and clinical research to identify stage\u2010dependent markers in the human disease course, investigate stage\u2010dependent interventions besides blood pressure lowering, and better understand the relationship between poor vascular health and neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.040710","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:23:45Z","timestamp":1764159825000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Vascular and Neural Transcriptomics Reveal Stage\u2010Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-6473","authenticated-orcid":false,"given":"Philipp","family":"Arndt","sequence":"first","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-3848","authenticated-orcid":false,"given":"Lorena","family":"Morton","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-8260","authenticated-orcid":false,"given":"Michael","family":"Briese","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2096-4640","authenticated-orcid":false,"given":"Naomi","family":"L\u00e4mmlin","sequence":"additional","affiliation":[{"name":"University Hospital Leipzig","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-4522","authenticated-orcid":false,"given":"Hendrik","family":"Mattern","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]},{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Hasanuzzaman","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Westhues","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsima","family":"Khoshneviszadeh","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-8692","authenticated-orcid":false,"given":"Silke","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-2325","authenticated-orcid":false,"given":"Daniel","family":"G\u00fcndel","sequence":"additional","affiliation":[{"name":"Department of Neuroradiopharmaceuticals","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-3857","authenticated-orcid":false,"given":"Magali","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Neuroradiopharmaceuticals","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-7058","authenticated-orcid":false,"given":"Peter","family":"Brust","sequence":"additional","affiliation":[{"name":"Department of Neuroradiopharmaceuticals","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-3455","authenticated-orcid":false,"given":"Torsten","family":"Kniess","sequence":"additional","affiliation":[{"name":"Department of Radiopharmaceutical and Chemical Biology","place":["Dresden, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Oelschlegel","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institute for Neurobiology","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institute for Neurobiology","place":["Magdeburg, Germany"]},{"name":"Center for Behavioral Brain Sciences (CBBS)","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-3501","authenticated-orcid":false,"given":"Sven","family":"Meuth","sequence":"additional","affiliation":[{"name":"Heinrich\u2010Heine\u2010University","place":["D\u00fcsseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-6532","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Braun\u2010Dullaeus","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-9821","authenticated-orcid":false,"given":"Grazyna","family":"Debska\u2010Vielhaber","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vielhaber","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Becker","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-0553","authenticated-orcid":false,"given":"Alexander","family":"Dityatev","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]},{"name":"Center for Behavioral Brain Sciences (CBBS)","place":["Magdeburg, Germany"]},{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-7276","authenticated-orcid":false,"given":"Solveig","family":"Henneicke","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-2974","authenticated-orcid":false,"given":"Michael","family":"Sendtner","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9900-8605","authenticated-orcid":false,"given":"Ildiko","family":"Dunay","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-4374","authenticated-orcid":false,"given":"Stefanie","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Otto\u2010von\u2010Guericke University","place":["Magdeburg, Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association","place":["Magdeburg, Germany"]},{"name":"Center for Behavioral Brain Sciences (CBBS)","place":["Magdeburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00248-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S90871"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215070"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00430-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.495457"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12629"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.82"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac584"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.727590"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14887"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12116"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006116"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000478529"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182815485"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000053"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201186"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000202010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30431-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(93)90001-O"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72639-7_13"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00148"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh553"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00533"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12384"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.27"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.122"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00411"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.014"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13812-z"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.067"},{"key":"e_1_3_2_37_2","volume-title":"ISMRM & SMRT Annual Meeting and Exhibition an Online Experience","author":"Mattern H","year":"2021","unstructured":"Mattern H. Openly available sMall vEsseL sEgmenTaTion pipelinE (OMELETTE). ISMRM & SMRT Annual Meeting and Exhibition an Online Experience. Concord, CA: International Society for Magnetic Resonance in Medicine; 2021."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0056195"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1109\/ICET.2011.6048487"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1145\/357994.358023"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25595-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120094"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121426"},{"key":"e_1_3_2_44_2","article-title":"Vessel distance mapping for deep gray matter structures","author":"Mattern H","year":"2021","unstructured":"Mattern H, Schreiber S, Speck O. Vessel distance mapping for deep gray matter structures. Proc Int Soc Magn Reson Med. 2021.","journal-title":"Proc Int Soc Magn Reson Med"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2003.1177156"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0212-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199908000-00005"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.010"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-112618-043515"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.038"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152383"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800165115"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6221-11.2012"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04888-5"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2018"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.053"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05858.x"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.11.002"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202205599"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12604"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101028"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22444-1"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.02.021"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201111079"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1446-8"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14574"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25739"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35901"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1295-x"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020124"},{"key":"e_1_3_2_78_2","first-page":"965","article-title":"Comparison of anxiety measured in the elevated plus\u2010maze, open\u2010field and social interaction tests between spontaneously hypertensive rats and Wistar EPM\u20101 rats","volume":"26","author":"Goto SH","year":"1993","unstructured":"Goto SH, Concei\u00e7\u00e3o IM, Ribeiro RA, Frussa\u2010Filho R. Comparison of anxiety measured in the elevated plus\u2010maze, open\u2010field and social interaction tests between spontaneously hypertensive rats and Wistar EPM\u20101 rats. Braz J Med Biol Res. 1993;26:965\u2013969.","journal-title":"Braz J Med Biol Res"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.06.003"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.03.026"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.002"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12221"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15073"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-5142"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019830321"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1752"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201802076"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312392"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0112-7"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001117R"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0169-8"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.3.498"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0497-x"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000124"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0632-z"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.006"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102883"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.2857"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00809"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170004"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02441-4"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.02.012"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221124644"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12521-4"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103503"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00900-1"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww349"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000234111.31239.c3"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.02.026"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-9981-y"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00281-1"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01257-z"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.010"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500004"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.136"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00702-6"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200667"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe5640"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02244-6"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.36"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90216-4"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm8302"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn5104"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00303-y"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0756-16.2017"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3209"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01150-1"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3311"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-019-00139-2"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.08.022"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90859-3"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220968"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25266"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.07.013"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-793"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011050"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303645"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-025-01332-6"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04369-3"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13905"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01497-3"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.040710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:09:44Z","timestamp":1782990584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.040710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":144,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1161\/JAHA.125.040710"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.040710","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040710"}}