{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:56:21Z","timestamp":1793336181386,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"\n Background<\/jats:title>\n Current anticancer treatments can result in cancer therapy\u2013related cardiac dysfunction (CTRCD). While glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) have demonstrated cardioprotective properties, their role in CTRCD has not been previously explored.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study utilized the TriNetX research network. Adults aged \u226518\u2009years who had a cancer history and who underwent antineoplastic therapy and developed CTRCD between January 1, 2012 and January 1, 2023 were included. Among patients on guideline\u2010directed medical therapy for heart failure, 2 groups were identified: GLP\u20101 RA users and nonusers. Propensity score matching (1:1) was conducted based on demographics, comorbid conditions, and concurrent medications, yielding a matched sample of 837 patients. Outcomes were assessed over a 1\u2010year follow\u2010up period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study cohort found 4982 patients with CTRCD; 837 received GLP\u20101 RA therapy (mean age: 69.0\u2009years; 43.8% female; 70.4% White). Compared with nonusers, those treated with GLP\u20101 RAs alongside guideline\u2010directed medical therapy had significantly lower rates of all\u2010cause mortality (hazard ratio, 0.57 [95% CI, 0.43\u20130.77];\n P<\/jats:italic>\n <0.001), acute heart failure exacerbations (hazard ratio, 0.69 [95% CI, 0.56\u20130.85];\n P<\/jats:italic>\n <0.001), and all\u2010cause hospitalizations (hazard ratio, 0.83 [95% CI, 0.72\u20130.96];\n P<\/jats:italic>\n =0.009). While reductions in atrial fibrillation\/flutter and ventricular tachycardia were observed, they were not statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Among patients with CTRCD receiving guideline\u2010directed medical therapy, GLP\u20101 RA use may be linked to better 1\u2010year survival and improved heart failure\u2013related outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.040919","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:01:56Z","timestamp":1762430516000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Role of GLP\u20101 Receptor Agonists in Managing Cancer Therapy\u2013Related Cardiac Dysfunction"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-0024","authenticated-orcid":false,"given":"Aravinthan","family":"Vignarajah","sequence":"first","affiliation":[{"name":"Cleveland Clinic Fairview Hospital","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-8665","authenticated-orcid":false,"given":"San","family":"Kim","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Fairview Hospital","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1914-0054","authenticated-orcid":false,"given":"Moath","family":"Albliwi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Fairview Hospital","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjun Max","family":"Ahn","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9796-9913","authenticated-orcid":false,"given":"Aleksandar","family":"Izda","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Naffa","sequence":"additional","affiliation":[{"name":"Ascension Health, Saint Agnes","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanthi","family":"Vigneswaramoorthy","sequence":"additional","affiliation":[{"name":"SUNY Upstate Medical University Hospital","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-9992","authenticated-orcid":false,"given":"Shimoli","family":"Barot","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-3950","authenticated-orcid":false,"given":"Gautam","family":"Shah","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation\/Fairview Hospital","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002661"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.012"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421502"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120505.91348.58"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.09.811"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103129"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.023"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10260"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.657"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.03.002"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.149"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S468453"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.040919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T04:19:03Z","timestamp":1766117943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.040919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":16,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,11,18]]}},"alternative-id":["10.1161\/JAHA.125.040919"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.040919","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"2025-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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