{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:45:55Z","timestamp":1794217555948,"version":"4.8.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac allograft vasculopathy (CAV) is the primary cause of limited long\u2010term survival among heart transplant recipients. This study aimed to evaluate the feasibility of\n              <jats:sup>18<\/jats:sup>\n              F\u2010FAPI\u201074 positron emission tomography\/computed tomography (PET\/CT) imaging for monitoring the fibrosis of CAV.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Rat models of CAV were established and 1 hour dynamic PET\/CT imaging was performed in the 15th week postoperation. Serial static\n              <jats:sup>18<\/jats:sup>\n              F\u2010FAPI\u201074 PET\/CT imaging in the allograft and isograft groups were performed from week 3 to 17. Blocking experiments were performed on allograft rats to confirm the tracer\u2019s targeting specificity. In\u00a0vivo PET\/CT imaging findings were further corroborated by ex\u00a0vivo PET\/CT imaging and biodistribution studies. Histological examination was conducted to validate the model\u2019s effectiveness, and the correlation between FAP expression levels and imaging results was ascertained.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Dynamic PET\/CT imaging revealed peak graft heart (Ht) uptake in the allograft group at 60\u2009minutes post\n              <jats:sup>18<\/jats:sup>\n              F\u2010FAPI\u201074 injection. PET\/CT imaging and biodistribution studies at all time points confirmed significantly higher radioactivity uptake in Ht of the allograft group, as compared with both their native hearts and Ht of the isograft group, and peaking at week 15. There was almost no radioactive accumulation of Ht in the allograft rats blocked by FAPI. Histological analysis confirmed significantly elevated FAP expression in Ht of the allograft group compared with the isograft group, consistent with the severity of CAV.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We successfully achieved molecular imaging of activated fibroblasts in CAV rat models, indicating that\n              <jats:sup>18<\/jats:sup>\n              F\u2010FAPI\u201074 PET\/CT may be a valuable means of evaluating fibrosis progression of CAV.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041169","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:30:58Z","timestamp":1759228258000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["<sup>18<\/sup>\n            F\u2010FAPI\u201074 Positron 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