{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:25:31Z","timestamp":1793042731812,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The impact of alcohol septal ablation (ASA) on exercise hemodynamics, symptoms, and quality of life in patients with obstructive hypertrophic cardiomyopathy is poorly described according to contemporary standards. This study aimed to evaluate the effect of ASA on filling pressures at rest and during exercise, left ventricular outflow tract obstruction, symptoms, and quality of life in patients with obstructive hypertrophic cardiomyopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This prospective study enrolled 24 patients with obstructive hypertrophic cardiomyopathy referred for ASA. Right\u2010heart catheterization and echocardiography were performed at rest and during exercise, before and \u22487\u2009months after ASA. The primary outcome was the difference in pulmonary artery wedge pressure at 75\u2009W. Secondary outcomes assessed left ventricular outflow tract gradients, New York Heart Association functional class, and the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              ASA significantly reduced pulmonary artery wedge pressure at 75\u2009W (33\u00b19\u2009mm\u2009Hg versus 24\u00b110\u2009mm\u2009Hg;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001), decreased left ventricular outflow tract gradients at rest (49 [interquartile range (IQR), 24\u201390] mm\u2009Hg versus 17 [IQR, 14\u201327] mm\u2009Hg;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.01), at peak exercise (45 [IQR, 29\u201390] mm\u2009Hg versus 32 [IQR, 21\u201361] mm\u2009Hg;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              \u2009=\u20090.02), and after exercise (96 [IQR, 34\u2013161] mm\u2009Hg versus 28 [IQR, 21\u201362] mm\u2009Hg;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.01). The Kansas City Cardiomyopathy Questionnaire Clinical Summary Score was significantly increased (65.4\u00b116 versus 76.7\u00b116;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.01). ASA improved New York Heart Association functional class, with 54% in class III before treatment, compared with 13% after treatment (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">ASA significantly reduced exercise\u2010induced filling pressures and LVOT obstruction, leading to improved symptoms and quality of life in patients with obstructive hypertrophic cardiomyopathy.,<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041328","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T06:31:26Z","timestamp":1755585086000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Alcohol Septal Ablation on Exercise Hemodynamics, Symptoms, and Quality of Life in Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-9725","authenticated-orcid":false,"given":"Anne M.","family":"Dybro","sequence":"first","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-7248","authenticated-orcid":false,"given":"Torsten B.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-3869","authenticated-orcid":false,"given":"Roni R.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]},{"name":"Health, Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-6789","authenticated-orcid":false,"given":"Bertil T.","family":"Ladefoged","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-5192","authenticated-orcid":false,"given":"Anders L. D.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Health, Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-9551","authenticated-orcid":false,"given":"Christian J.","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]},{"name":"Health, Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-8227","authenticated-orcid":false,"given":"Mads J.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus N, Denmark"]},{"name":"Health, Aarhus 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