{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:13Z","timestamp":1787018113075,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiogenic shock (CS) is a critical condition associated with high mortality rates, making prompt diagnosis essential for timely interventions that may improve patient outcomes. The Society for Cardiovascular Angiography and Interventions (SCAI) SHOCK Stage Classification is a validated tool for assessing CS and predicting patient outcomes. Here, we evaluated how different parameter definitions affect SCAI stage adjudication, hypothesizing that variations may influence stage determination and the overall assessment of CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">All patients diagnosed with CS or conditions leading to CS at the University Medical Center Mannheim, Germany, from January 2018 to June 2022 were included in the study. SCAI SHOCK stages were assigned retrospectively on the basis of 4 previously published studies. The distribution of SCAI SHOCK stages, outcomes, classification concordance, and predictive performance were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      From January 2018 to June 2022, we identified 1303 patients on the basis of\n                      <jats:italic toggle=\"no\">International Classification of Diseases<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"no\">Tenth Revision<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"no\">ICD\u201010<\/jats:italic>\n                      ) codes. Of these, 1281 patients (98.2%) were classified into SCAI SHOCK stages according to all 4 classification frameworks. While the assignment of SCAI SHOCK stages and associated mortality rates varied among the frameworks, Kendall's W indicated moderate to strong overall classification agreement (W=0.70). There was no significant difference in predictive performance for in\u2010hospital death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our study demonstrates a moderate to strong concordance and comparable prognostic performance across different SCAI SHOCK Stage Classification frameworks in evaluating patients with CS. Despite differences in stage assignments, all frameworks effectively stratified patients by clinical severity. Comparable stage assignment in retrospective studies requires further standardization of the SCAI SHOCK Stage Classification system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041340","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:23:23Z","timestamp":1755926603000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Consistency and Risk Stratification Performance of 4 Society for Cardiovascular Angiography and Interventions SHOCK Stage Definitions: A Retrospective Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-757X","authenticated-orcid":false,"given":"Tobias","family":"Becher","sequence":"first","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1286-1835","authenticated-orcid":false,"given":"Leonie","family":"Hahn","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7257-6057","authenticated-orcid":false,"given":"Markward","family":"Britsch","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Mannheim Institute for Intelligent Systems in Medicine (MIISM), Heidelberg University","place":["Heidelberg, Germany"]},{"name":"HMS Analytical Software GmbH","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Muschko","sequence":"additional","affiliation":[{"name":"Department of Mobile User Experience (UX)\/EMEA","place":["Walldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald F.","family":"Langer","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lindner","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Helbing","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hahn","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4012","authenticated-orcid":false,"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2212-4114","authenticated-orcid":false,"given":"Simone","family":"Britsch","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]},{"name":"Helmholtz\u2010Institute for Translational AngioCardioScience (HI\u2010TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University","place":["Heidelberg, 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Extracorporeal life support in infarct\u2010related cardiogenic shock. N Engl J Med. 2024;390:190.","journal-title":"N Engl J Med"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28329"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28707"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29139"},{"key":"e_1_3_2_10_2","first-page":"E288","article-title":"SCAI cardiogenic shock classification after out of hospital cardiac arrest and association with outcome","volume":"97","author":"Pareek N","year":"2021","unstructured":"Pareek N, Dworakowski R, Webb I, Barash J, Emezu G, Melikian N, Hill J, Shah A, MacCarthy P, Byrne A. SCAI cardiogenic shock classification after out of hospital cardiac arrest and association with outcome. 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