{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:33Z","timestamp":1782992733724,"version":"3.54.5"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"\n Background<\/jats:title>\n Intensive systolic blood pressure (SBP) treatment could mitigate the increased cardiovascular disease risk associated with long\u2010standing hypertension. Target organ damage serves as a critical intermediate phenotype in hypertension\u2010related sequelae. However, the associations of hypertension duration on the cardiac, vascular, and kidney organ damage improvement of intensive SBP treatment remains to be elucidated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 8442 STEP (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) participants with complete hypertension duration data were categorized by hypertension duration \u22645\u2009years, 5~10\u2009years, 10~15\u2009years, and >15\u2009years. Patients were randomly assigned to intensive or standard SBP treatment groups after enrollment. Odds ratios (ORs) for left ventricular hypertrophy, arterial stiffness, and chronic kidney disease were calculated using a logistic regression model, testing for effect modification by hypertension duration.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For left ventricular hypertrophy, no evidence showed heterogeneity among groups with different hypertension duration in the treatment effect between intensive versus standard treatment for either new\u2010onset or improvement (both\n P<\/jats:italic>\n for interaction >0.05). For arterial stiffness, intensive versus standard SBP treatment showed significantly greater benefits in preventing new\u2010onset arterial stiffness in early\u2010stage (\u22645\u2009years: 29.46% versus 36.81%; OR, 0.67 [95% CI, 0.47\u20130.95]) and long\u2010standing hypertension (>15\u2009years: 30.88% versus 41.23%; OR, 0.62 [95% CI, 0.45\u20130.84]) compared with the intermediate stage (\n P<\/jats:italic>\n for interaction=0.03). For kidney events, no treatment interaction effects or significant associations with hypertension duration were observed (\n P<\/jats:italic>\n for interaction >0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Intensive SBP treatment showed greater benefits in preventing new\u2010onset arterial stiffness in both early\u2010stage (\u22645\u2009years) and long\u2010standing (>15\u2009years) hypertension, whereas no heterogeneity was identified among groups with hypertension for left ventricular hypertrophy and kidney events.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT03015311.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.041556","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:32:43Z","timestamp":1773401563000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Hypertension Duration on the Associations Between Intensive Blood Pressure Control and Cardiac, Vascular, and Kidney Organ Damage"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-3934","authenticated-orcid":false,"given":"Qianhui","family":"Ling","sequence":"first","affiliation":[{"name":"Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-9163","authenticated-orcid":false,"given":"Yue","family":"Deng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-1774","authenticated-orcid":false,"given":"Xilan","family":"Dong","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9340-4520","authenticated-orcid":false,"given":"Qirui","family":"Song","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-9570","authenticated-orcid":false,"given":"Jun","family":"Cai","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18786"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2019.03.014"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy877"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.948707"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2020.1733648"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111437"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","unstructured":"Deng Y Liu W Yang X Guo Z Zhang J Huang R Yu C Yu J Cai J. 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