{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:54:07Z","timestamp":1793332447026,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The IVUS\u2010DCB (Intravascular Ultrasound\u2010Guided Drug\u2010Coated Balloon Angioplasty for Femoropopliteal Artery Disease) trial found that intravascular ultrasound (IVUS)\u2013guided drug\u2010coated balloon (DCB) angioplasty was associated with superior 12\u2010month outcomes, compared with conventional angiography\u2010guided DCB angioplasty. However, the durability of these benefits remains uncertain. The aim of this study was to compare the 24\u2010month outcomes of IVUS\u2010guided versus angiography\u2010guided DCB angioplasty for femoropopliteal artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This extended study analyzed a total of 237 patients who were previously randomized into IVUS\u2010guidance (n=119) or angiography\u2010guidance (n=118) groups in the original IVUS\u2010DCB trial. The 24\u2010month clinical efficacy outcomes included freedom from clinically driven target lesion revascularization, sustained clinical and hemodynamic improvements, and freedom from major amputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      At 24\u2010month follow\u2010up, the IVUS\u2010guidance group exhibited significantly higher rates of freedom from clinically driven target lesion revascularization (87.4% versus 78.0%; hazard ratio, 0.46 [95% CI, 0.24\u20130.88];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02), sustained clinical improvement (82.4% versus 71.2%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02), and sustained hemodynamic improvement (74.8% versus 61.0%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01), compared with the angiography\u2010guidance group. No major amputations occurred in either group during the 24\u2010month follow\u2010up. There were no significant differences in safety outcomes between groups, including all\u2010cause death, cardiovascular death, and major bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">At 24\u2010month follow\u2010up, IVUS\u2010guided DCB angioplasty for femoropopliteal artery disease continued to demonstrate superior outcomes, compared with angiography\u2010guided DCB angioplasty, in terms of freedom from clinically driven target lesion revascularization, sustained clinical improvement, and sustained hemodynamic improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041564","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:30:31Z","timestamp":1754998231000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Twenty\u2010Four\u2013Month Outcomes of Intravascular Ultrasound\u2010Guided Drug\u2010Coated Balloon Angioplasty for Femoropopliteal Artery Disease"],"prefix":"10.1161","volume":"14","author":[{"given":"Jonghu","family":"Shin","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-4370","authenticated-orcid":false,"given":"Chul\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, 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