{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:45:12Z","timestamp":1787589912334,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The clinical benefits of mavacamten in patients with obstructive hypertrophic cardiomyopathy previously treated with advanced therapies are not established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Clinical and echocardiographic outcomes of patients treated with mavacamten for left ventricular outflow obstruction for at least 8\u2009weeks were assessed based on prior treatment with one or more advanced therapies: disopyramide, septal myectomy, alcohol septal ablation, dual\u2010chamber ventricular pacing with short atrioventricular delay; we also evaluated patients with left ventricular outflow obstruction that emerged as major driver of symptoms after aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included 115 consecutive patients (mean age 66\u00b112\u2009years, 57% women, wall thickness 17\u00b14\u2009mm) on mavacamten for a median 45 (interquartile range, 22\u201361) weeks, of whom 53 (46%) patients were previously on disopyramide (n=45); underwent septal myectomy (n=8), alcohol septal ablation (n=6), or forced ventricular pacing (n=11); and 5 had previous aortic valve replacement. New York Heart Association class improved from 2.6\u00b10.5 to 1.8\u00b10.6 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001) in those with and without prior advanced therapy. Left ventricular systolic dysfunction (ejection fraction &lt;50%) occurred in 12 (10%) patients, 8 (15%) in the advanced treatment group and 4 (7%) in those without (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.13). Maximal provoked peak left ventricular outflow gradients decreased from 103 (77\u2013130) mm\u2009Hg to 11 (8\u201321) mm\u2009Hg in patients with prior advanced therapy and from 101 (81\u2013130) mm\u2009Hg to 13 (8\u201325) mm\u2009Hg in those without (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mavacamten is a safe and effective treatment for symptomatic left ventricular outflow obstruction in patients with obstructive hypertrophic cardiomyopathy resistant to previous advanced pharmacologic therapy, surgery, or alcohol septal ablation or who develop manifest left ventricular outflow obstruction after aortic valve replacement.<\/jats:p>\n                  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USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumar","family":"Frejat","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-2600","authenticated-orcid":false,"given":"Maria C.","family":"Reuter","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-7648","authenticated-orcid":false,"given":"Yuhe","family":"Xia","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-7780","authenticated-orcid":false,"given":"Mark V.","family":"Sherrid","sequence":"additional","affiliation":[{"name":"NYU Langone Health","place":["New York, 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