{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:54:09Z","timestamp":1792853649541,"version":"4.5.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Estimated pulse wave velocity (ePWV), a marker of arterial stiffness, is strongly associated with cardiovascular events and all\u2010cause death in the general population. This study evaluates the association of arterial stiffness, defined by the ePWV equation, with all\u2010cause and cardiovascular death and identifies an optimal ePWV threshold for risk stratification in cancer survivors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Using data from the National Health and Nutrition Examination Survey (2009\u20132018), we analyzed a cohort representing more than 105\u2009million US cancer survivors. Multivariable Cox regression and Kaplan\u2013Meier analyses assessed the association between ePWV and outcomes. Dose\u2010dependent relationships were explored, and an optimal ePWV threshold was determined through maximally selected rank statistics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              During a median follow\u2010up of 59\u2009months, a total of 105\u2009869\u2009670 weighted cancer survivors (2234 unweighted) were analyzed, recording 435 all\u2010cause and 91 cardiovascular deaths. Early vascular aging (ePWV \u22659.4\u2009m\/s) was present in 54.6% of participants. Each 1\u2009m\/s increase in ePWV was associated with higher risks of all\u2010cause death (29%) and cardiovascular death (46%) (hazard ratio [HR], 1.29 [95% CI, 1.19\u20131.40] and 1.46 [95% CI, 1.20\u20131.76], respectively, both\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). Those with ePWV \u226512.05\u2009m\/s demonstrated higher risks of all\u2010cause and cardiovascular death (HR, 1.70 [95% CI, 1.35\u20132.13] and 2.53 [95% CI, 1.56\u20134.12], respectively, both\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Arterial stiffness, assessed by ePWV, demonstrates prognostic utility in cancer survivors, showing a nonlinear association with all\u2010cause and cardiovascular death, independent of demographic, socioeconomic, traditional cardiovascular risk factors not included in the ePWV equation, and baseline cardiovascular disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041645","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:16:07Z","timestamp":1758280567000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Arterial Stiffness in Cancer Survivors: The Prognostic Value of Estimated Pulse Wave Velocity in US Cancer Population From the National Health and Nutrition Examination Survey 2009 to 2018"],"prefix":"10.1161","volume":"14","author":[{"given":"Mustafa","family":"Al\u2010jarshawi","sequence":"first","affiliation":[{"name":"Keele University","place":["Stoke\u2010on\u2010Trent, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhmetzhan","family":"Galimzhanov","sequence":"additional","affiliation":[{"name":"Keele University","place":["Stoke\u2010on\u2010Trent, UK"]},{"name":"Outpatient Clinic #7, Department of Internal Medicine Semey Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-6010","authenticated-orcid":false,"given":"Marco","family":"Zimarino","sequence":"additional","affiliation":[{"name":"SS.Annunziata Hospital\u2014ASL and University \u201cG. D\u2019Annunzio\u201d of Chieti","place":["Chieti, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-7591","authenticated-orcid":false,"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Diaz\u2010Arocutipa","sequence":"additional","affiliation":[{"name":"Universidad San Ignacio de Loyola","place":["Lima, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-498X","authenticated-orcid":false,"given":"Ofer","family":"Kobo","sequence":"additional","affiliation":[{"name":"Keele University","place":["Stoke\u2010on\u2010Trent, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele University","place":["Stoke\u2010on\u2010Trent, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206916"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0409"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20150011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcad036"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03328-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/LIFEMEDI\/LNAD033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14971"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.099031"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002449"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X0100600402"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18776"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08917"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2016-000045"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHAE178"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.035"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2023.1145914"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANETWORKOPEN.2019.12831"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-018-19457-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0280896"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/EHJQCCO\/QCAE076"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1140160"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-18071-2"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.025173"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/JCM13123377"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2387932"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igac056"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCHY.2021.100085"},{"key":"e_1_3_2_32_2","first-page":"1","article-title":"The National Health and nutrition examination survey: sample design, 1999\u20102006","author":"Curtin LR","year":"2012","unstructured":"Curtin LR, Mohadjer LK, Dohrmann SM, et\u00a0al. 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