{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:55:58Z","timestamp":1761710158858,"version":"3.41.2"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:sec id=\"jah311001-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Body composition abnormalities are associated with the risk of Alzheimer's disease\u2010related dementia (ADRD). However, the specific link between osteosarcopenic adiposity (OSA), cardiovascular health (CVH), and ADRD is underexplored. This study examined the association between OSA and ADRD to determine whether optimal CVH could modify this association.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311001-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed data from 152\u2009028 UK Biobank participants. OSA\u2010related body composition abnormalities include low bone mineral density, low muscle mass\/grip strength, and high body fat percentage. CVH was assessed using the Life's Essential 8 questionnaire. High and low CVH corresponded to the lowest and highest cardiovascular disease risks, respectively. The hazard ratios (HRs) and 95% CIs for ADRD were estimated using Cox proportional hazards models. A secondary analysis included 14\u2009750 participants with brain magnetic resonance imaging data to explore the role of brain structure in the association between OSA and the incidence of ADRD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311001-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              After a median follow\u2010up of 14.1\u2009years, 2628 participants (1.73%) developed ADRD. Compared with participants with no body composition abnormalities, the adjusted HRs for ADRD risk for those with 1, 2, and 3 abnormalities were 1.04 (95% CI, 0.95\u20131.14), 1.17 (95% CI, 1.04\u20131.31), and 1.46 (95% CI, 1.11\u20131.92), respectively. We found a significant addictive interaction between CVH and abnormal body components, with a relative excess risk due to interaction (95% CI) of \u22121.34 (95% CI, \u22122.11 to \u22120.57). Gray matter in the hippocampus could mediate these associations, with a mediation proportion of 17.3% (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              \u2009&lt;\u20090.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311001-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">OSA components are positively associated with the risk of ADRD. Maintaining optimal CVH status may mitigate ADRD risk in individuals with OSA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041697","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:35:54Z","timestamp":1747910154000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease\u2010Related Dementia: A UK Biobank Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Wenxu","family":"Wang","sequence":"first","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"China Medical University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ren","sequence":"additional","affiliation":[{"name":"China Medical 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenying","family":"Wang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease","place":["Shenyang, 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