{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:10:51Z","timestamp":1780488651907,"version":"3.54.1"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Population\u2010based data on bicuspid aortic valve (BAV)\u2010attributable mortality trends in the United States are limited. This study assessed trends in BAV\u2010attributable death in the United States from 2010 to 2020, evaluating differences by sex, ethnicity, urbanization, and census region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Data were extracted from the Centers for Disease Control and Prevention's Wide\u2010Ranging Online Data for Epidemiologic Research system. Trends in age\u2010adjusted mortality rates per 100\u2009000 population were analyzed using JoinPoint regression to calculate average annual percentage change and annual percentage change, with corresponding 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      From 2010 and 2020, 3537 deaths were attributable to BAV, corresponding to 11.7 deaths per 100\u2009000 population. Age\u2010adjusted mortality rates increased linearly, with an average annual percentage change of +4.6% (95% CI, 2.8\u20136.5;\n                      <jats:italic toggle=\"no\">P&lt;<\/jats:italic>\n                      0.001). Women experienced a steeper increase (average annual percentage change, +8.0% [95% CI, 3.3\u201312.9];\n                      <jats:italic toggle=\"no\">P&lt;<\/jats:italic>\n                      0.001) compared with men (average annual percentage change, +5.3% [95% CI, 3.6\u20137.0];\n                      <jats:italic toggle=\"no\">P&lt;<\/jats:italic>\n                      0.001). Mortality trends were more pronounced among Hispanic\/Latinx individuals and those aged &lt;65\u2009years. No significant differences between urban and rural settings were observed (\n                      <jats:italic toggle=\"no\">P=<\/jats:italic>\n                      0.35), while the South accounted for the highest proportion of deaths (31.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">BAV\u2010attributable mortality has increased over the past decade, with significant disparities by sex, age, and region. These results highlight the critical importance of developing targeted health care approaches and enhancing strategic management techniques to address specific population BAV\u2010related health concerns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041725","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:45:28Z","timestamp":1761648328000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Bicuspid Aortic Valve\u2013Attributable Death in the United States From 2010 to 2020"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-1292","authenticated-orcid":false,"given":"Marco","family":"Zuin","sequence":"first","affiliation":[{"name":"University of Ferrara","place":["Ferrara, Italy"]},{"name":"University of Padova","place":["Padua, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7894-3565","authenticated-orcid":false,"given":"Umberto","family":"Campia","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-2797","authenticated-orcid":false,"given":"Kim I.","family":"De la Cruz","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia, School of Medicine","place":["Charlottesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-9872","authenticated-orcid":false,"given":"Michael","family":"Singh","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-5276","authenticated-orcid":false,"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.27205"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2022.100119"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.04.025"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/145202"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309916"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740878"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2024.107604"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.02.115"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvdhj.2021.03.003"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.068"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.122.009162"},{"key":"e_1_3_1_14_2","unstructured":"Census Bureau Population Division . 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