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The device features a cobalt\u2013chromium scaffold connected by bioresorbable polymer elements that degrade 6 months after implantation. This process unlocks helical strands, enabling vessel pulsatility, compliance, and adaptive remodeling while maintaining lumen integrity. Preclinical studies demonstrated reduced vessel stress and restored physiological rotational motion. In the DYNAMIX (12\u2010Month Clinical and Imaging Outcomes of the Uncaging Coronary DynamX Bioadaptor System) study, patients exhibited increased vessel area without lumen loss, optimal strut apposition, and complete neointimal coverage at 12 months. The small BIOADAPTOR\u2010RCT (Randomized Controlled Trial of Sirolimus\u2010Eluting Bioadaptor Versus Zotarolimus\u2010Eluting Drug\u2010Eluting Stent) showed noninferiority to drug\u2010eluting stents with superior late lumen preservation and reduced neointimal hyperplasia. The larger INFINITY\u2010SWEDEHEART (Percutaneous Coronary Intervention With a Bioadaptor Compared to a Contemporary Drug\u2010Eluting Stent) trial confirmed low target\u2010lesion failure rates and a plateauing of adverse events after 6 months, highlighting the benefits of vessel motion restoration. The DynamX coronary bioadaptor may represent a significant advancement in percutaneous coronary intervention by providing early mechanical support and restoring vessel function. Further studies on complex anatomy and long\u2010term outcomes are needed to further define its role in interventional cardiology.<\/jats:p>","DOI":"10.1161\/jaha.125.041843","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:45:06Z","timestamp":1775727906000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["From Caging to Uncaging With Bioadaptors: A Novel Paradigm in Coronary Revascularization"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-4224","authenticated-orcid":false,"given":"Placido Maria","family":"Mazzone","sequence":"first","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Policlinico \u201cG. 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