{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:48:38Z","timestamp":1787579318482,"version":"build-2736575974"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Substance use is associated with cardiac disease, and women with HIV have a disproportionately high prevalence of substance use. However, the extent to which ongoing use of multiple substances relates to specific cardiovascular conditions in women with HIV and sociodemographically similar women without HIV (\u201cat risk for HIV\u201d) remains understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We measured left ventricular systolic dysfunction (LVSD) and diastolic dysfunction (LVDD), conditions that precede clinical heart failure, among 1651 participants of the multisite WIHS (Women's Interagency HIV Study). Using standardized echocardiography, we determined associations between the use of substances (stimulants, opioids, tobacco, alcohol, sedatives) reported at \u22652 biannual visits (\u201csustained use\u201d) and left ventricular dysfunction. LVSD was defined as left ventricular ejection fraction &lt;54%, and LVDD was considered in the absence of LVSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Most participants (75%) identified as non\u2010Hispanic Black, the average age was 49\u2009years, 70% had HIV, and 4.9% had LVSD. In adjusted analysis, none of the sustained substance use categories were significantly associated with LVSD. Among women without LVSD, 6.6% had LVDD. The adjusted odds of LVDD were 6.82 times higher (95% CI, 5.47\u20138.50) among women with sustained methamphetamine\/amphetamine use. Among women with HIV only, the adjusted odds for methamphetamine\/amphetamine were 5.31 (95% CI, 4.21\u20136.70), and adjusted odds for cigarette use were 1.87 (95% CI, 1.39\u20132.52).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this national sample of women with and without HIV, sustained methamphetamine\/amphetamine use had an especially strong association with LVDD that was independent of cigarette use. Routine assessment of methamphetamine\/amphetamine use in vulnerable women may improve heart failure risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041888","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:17:39Z","timestamp":1772101059000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Associations Between Sustained Methamphetamine\/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-1155","authenticated-orcid":false,"given":"Elise D.","family":"Riley","sequence":"first","affiliation":[{"name":"University of California","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ma","sequence":"additional","affiliation":[{"name":"University of 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