{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T21:58:38Z","timestamp":1787522318588,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To date, the role of MOTS\u2010c (mitochondrial open reading frame of the 12S ribosomal RNA type\u2010c) in acute coronary syndrome remains largely unknown. We measured circulating MOTS\u2010c levels, markers of oxidative stress, and blood biochemical parameters in patients with acute coronary syndrome and examined their relationship with major adverse cardiac events (MACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results. Serum MOTS\u2010c and thiobarbituric acid reactive substances were measured upon initial admission. Hospitalization data, major adverse cardiac events, and a follow\u2010up duration of 18 months were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The serum levels of MOTS\u2010c and thiobarbituric acid reactive substances were higher in patients with acute coronary syndrome and there was a positive correlation between MOTS\u2010c and thiobarbituric acid reactive substances. In addition, MOTS\u2010c levels showed a high sensitivity of 0.890 (cutoff value, 326.65 [95% CI, 253.41\u2013631.84]; area under the curve, 0.739 [95% CI, 0.647\u20130.832],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) in predicting the occurrence of unstable angina and acute myocardial infarction in the general population. Our data also showed that MOTS\u2010c\/thiobarbituric acid reactive substances levels could be used to predict major adverse cardiac events in the group with acute myocardial infarction, with a sensitivity of 0.800 and specificity of 0.667 (cutoff value, 48.26 ng\/umol [95% CI, 45.43\u201390.16 ng\/umol]; area under the curve, 0.718 [95% CI, 0.598\u20130.839],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.003). In\u00a0vitro studies demonstrated that oxidative stress induces MOTS\u2010c levels and MOTS\u2010c treatment reduces hypoxia\u2010induced oxidative stress through activating antioxidants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The circulating MOTS\u2010c is associated with an increased risk of acute coronary syndrome and the imbalance between oxidative stress and circulating MOTS\u2010c may play a role in predicting major adverse cardiac events in patients with acute myocardial infarction.<\/jats:p>\n                  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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3935-3448","authenticated-orcid":false,"given":"Bojian","family":"Wang","sequence":"additional","affiliation":[{"name":"Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Nanjing Medical University","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Yang","sequence":"additional","affiliation":[{"name":"Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tong","sequence":"additional","affiliation":[{"name":"First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-8892","authenticated-orcid":false,"given":"Zhenwei","family":"Gong","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Children\u2019s Hospital of Pittsburgh","place":["Pittsburgh, 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