{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:09:19Z","timestamp":1782943759895,"version":"3.54.5"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Iatrogenic cerebral amyloid angiopathy (iCAA) is a subform of cerebral amyloid angiopathy caused by exposure to amyloid \u03b2. The aim of this study was to assess cerebrospinal fluid amyloid and \u03c4 concentrations in iCAA in comparison with sporadic cerebral amyloid angiopathy (sCAA), Alzheimer disease (AD), and controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted a systematic literature review to identify patients with iCAA with published cerebrospinal fluid marker concentrations. We then analyzed the cerebrospinal fluid concentrations of amyloid \u03b240, amyloid \u03b242, total \u03c4, and phosphorylated \u03c4 181, comparing them with the corresponding data of patients with sCAA, AD, and controls from our previous work.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The study included 25 patients with iCAA (age, 44\u00b111\u2009years), 31 patients with sCAA (age, 75\u00b15\u2009years), 28 patients with AD (age, 71\u00b18\u2009years) and 30 controls (age, 72\u00b18\u2009years) from 9 case descriptions and 1 cohort study. Amyloid \u03b240 concentrations did not differ significantly between iCAA and the other groups. Amyloid \u03b242 concentration was significantly higher in controls than iCAA and the other groups. The amyloid \u03b242\/40 ratio was higher in iCAA than in AD and higher in controls than sCAA and AD. Total \u03c4 concentrations were lower in controls than iCAA but did not differ significantly between iCAA, sCAA, and AD. Phosphorylated \u03c4 concentrations were not significantly different in iCAA compared with controls, significantly higher in sCAA, and highest in AD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The observation that phosphorylated \u03c4 concentrations in iCAA are not different from controls led us to the hypothesis that iCAA is characterized by amyloid plaque formation largely without concomitant phosphorylated \u03c4 aggregation, which is well compatible with most published pathologic studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041908","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:46:32Z","timestamp":1753789592000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebrospinal Fluid \u03b2\u2010Amyloid and \u03c4 Levels in Patients With Iatrogenic Cerebral Amyloid Angiopathy, Sporadic Cerebral Amyloid Angiopathy, Alzheimer Disease, and Controls"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-4410","authenticated-orcid":false,"given":"Ulf","family":"Jensen\u2010Kondering","sequence":"first","affiliation":[{"name":"Campus L\u00fcbeck","place":["L\u00fcbeck, Germany"]},{"name":"Campus Kiel","place":["Kiel, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-1079","authenticated-orcid":false,"given":"Nils G.","family":"Margraf","sequence":"additional","affiliation":[{"name":"Campus Kiel, Kiel University","place":["Kiel, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-3635","authenticated-orcid":false,"given":"Slaven","family":"Pikija","sequence":"additional","affiliation":[{"name":"Christian Doppler University Hospital","place":["Salzburg, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Rak\u2010Frattner","sequence":"additional","affiliation":[{"name":"Krankenhaus der Barmherzigen Br\u00fcder","place":["Eisenstadt, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-8301","authenticated-orcid":false,"given":"Branko","family":"Malojcic","sequence":"additional","affiliation":[{"name":"Zagreb School of Medicine, University Hospital Center","place":["Zagreb, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-160X","authenticated-orcid":false,"given":"Senta","family":"Frol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Medical Centre Ljubljana","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-2173","authenticated-orcid":false,"given":"Janja","family":"Pretnar\u2010Oblak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Medical Centre Ljubljana","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-868X","authenticated-orcid":false,"given":"Patricia","family":"de la Riva","sequence":"additional","affiliation":[{"name":"Donostia University Hospital, Neurovascular Diseases, Biogipuzkoa Health Research Institute","place":["San Sebasti\u00e1n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-1775","authenticated-orcid":false,"given":"Ines","family":"Albajar Gomez","sequence":"additional","affiliation":[{"name":"Donostia University Hospital, Neurovascular Diseases, Biogipuzkoa Health Research 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Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-2122","authenticated-orcid":false,"given":"Benedetta","family":"Storti","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","place":["Milan, 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