{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:14:50Z","timestamp":1793369690128,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The constant resistance ratio (cRR) is a novel nonhyperemic pressure ratio based on piezoresistive pressure microcatheter (PMC) measurements. With repeated measurements in randomized order of PMC and pressure wire techniques, this study aimed primarily to validate the diagnostic performance of cRR compared with fractional flow reserve (FFR) in coronary lesions of 30% to 90% diameter stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">SUPREME II (Sensor\u2010Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a multicenter, prospective study that included 466 patients (483 vessels) from 11 centers. All target vessels were assessed using both pressure wire and PMC separately in randomized order under resting and hyperemic conditions. The primary end point was the diagnostic accuracy of the cRR using a PMC\u2010based FFR of \u22640.80 as the reference standard. Secondary end points included the cRR \u201cgray zone\u201d of the cRR\u2013FFR hybrid strategy and the proportion of patients in whom diagnosed was achieved without vasodilator use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The optimal cRR cutoff was 0.89, which correctly classified 82.8% of the patients, with a sensitivity and specificity of 87.0% and 80.1%, respectively, and achieved an area under the curve of 0.92 with FFR\n                      <jats:sub>PMC<\/jats:sub>\n                      as reference (area under the curve 0.90 with FFR\n                      <jats:sub>pressure wire<\/jats:sub>\n                      as reference). If FFR was added for decision\u2010making in cases of cRR values between 0.85 and 0.91, a cRR\u2013\u2010FFR hybrid strategy achieved a 95.3% agreement with the FFR\u2010only strategy and allowed 68.5% of the patients to not require using vasodilator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In coronary stenosis of 30% to 90% diameter stenosis, cRR measurements were highly feasible. The diagnostic accuracy of cRR with FFR\n                      <jats:sub>PMC<\/jats:sub>\n                      as reference was excellent. Further, a cRR\u2013FFR hybrid strategy may reduce vasodilator use without compromising diagnostic accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05417763\">https:\/\/clinicaltrials.gov\/study\/NCT05417763<\/jats:ext-link>\n                      ; Unique Identifier: NCT05417763.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041920","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:36:37Z","timestamp":1773401797000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Validation of a Novel Pressure Microcatheter\u2010Based Nonhyperemic Pressure Ratio (SUPREME II Study)"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-4329","authenticated-orcid":false,"given":"Jinying","family":"Zhou","sequence":"first","affiliation":[{"name":"Zhongshan Hospital, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-9629","authenticated-orcid":false,"given":"Junqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial People\u2019s Hospital","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zunyi Medical College","place":["Zunyi, 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