{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:00:50Z","timestamp":1780592450382,"version":"3.54.1"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The purpose of this study was to estimate the prevalence and number of cerebral microbleeds (CMBs) in a Hispanic and Latino cohort from various self\u2010identified backgrounds and test associations with age, vascular risk factors, APOE (apolipoprotein E), and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The 3T brain magnetic resonance imaging exams were obtained on SOL\u2010INCA\u2010MRI (Study of Latinos\u2010Investigation of Neurocognitive Aging\u2010MRI) magnetic resonance imaging study participants, a community\u2010based study. CMB number was counted and categorized as: (1) any CMB, (2) lobar only, (3) deep only, (4) mixed, (5) deep+mixed, and (6) lobar+mixed. We examined whether prevalence of CMBs varied by age, sex, education, Hispanic background, cardiovascular risk factors (hypertension, diabetes, Framingham Risk Score), APOE genotype, and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 2455 participants were included who were 63.0\u00b18.4\u2009years of age, 67.9% women, and 62.2% high school education or higher. CMBs prevalence was 11.7% (8.3% lobar only, 2.0% deep only, 1.4% mixed locations). After adjusting for age, sex, and education, a high Framingham Risk Score was associated with the presence of CMBs of all types, except lobar only. Prevalent stroke\/transient ischemic attack was associated with higher likelihood of deep\u2010only CMBs. For participants with cognitive impairment, the adjusted prevalence of mixed CMBs (2.2% versus 1.1%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.023) and deep\u2010only+mixed CMBs (5.2% versus 3.1%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.010) was significantly higher compared with cognitively normal. Cognitive impairment was significantly associated with higher total CMB count (rate ratio, 1.46 [95% CI, 1.14\u20131.87];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.003). No significant associations were found between diabetes, APOE4, and any CMB type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">High vascular risk scores, self\u2010reported history of stroke\/transient ischemic attack, and cognitive status were associated with a higher likelihood of CMBs, especially in deep regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041934","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:02:43Z","timestamp":1770807763000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Cerebral Microbleeds and Association With Vascular Risk Factors in a Hispanic and Latino American 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