{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:10:36Z","timestamp":1788012636061,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Stroke is a recognized complication following transcatheter aortic valve replacement (TAVR). Although women have historically had a higher rate of bleeding and vascular complications after TAVR, contemporary data on sex differences in post\u2010TAVR stroke and stroke severity are lacking. Disabling strokes significantly affect quality of life and outcomes, underscoring the need to explore sex\u2010specific variations in post\u2010TAVR stroke risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">In this retrospective cohort study, we included all patients who underwent TAVR in the National Inpatient Sample from 2016 to 2021. Stroke and stroke severity were ascertained using validated claims\u2010based algorithms. Disabling strokes were defined as those resulting in death or discharge to a nonhome location. We used multivariable logistic regression to evaluate the association between sex and stroke while adjusting for covariates, including cerebral embolic protection use, and accounting for survey weights.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Among our weighted sample of 379\u2009410 patients (43.9% female), women demonstrated higher overall in\u2010hospital stroke incidence compared with men (2.31% versus 1.69%; adjusted odds ratio [aOR], 1.208 [95% CI, 1.082\u20131.350]). This difference was driven primarily by disabling strokes, which were more common in women (1.61% versus 1.01%; aOR, 1.327 [95% CI, 1.158\u20131.520]). Conversely, the incidence of nondisabling stroke was not statistically different between sexes (0.70% versus 0.67%;( aOR, 1.013 [95% CI, 0.844\u20131.215]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients undergoing TAVR in contemporary practice, women had a higher rate of any stroke and disabling strokes compared with men. These findings emphasize the need for tailored strategies to mitigate stroke risk and improve outcomes for female TAVR patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041943","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:04:17Z","timestamp":1752753857000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Sex Differences in Stroke Frequency and Severity Following Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"14","author":[{"given":"Vijay A.","family":"Joshi","sequence":"first","affiliation":[{"name":"University of Colorado School of Medicine","place":["Aurora, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-3597","authenticated-orcid":false,"given":"Emily M.","family":"Bucholz","sequence":"additional","affiliation":[{"name":"University of Colorado School of 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J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Saint Francis Hospital","place":["Rosslyn, USA"]},{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-4873","authenticated-orcid":false,"given":"Stephen W.","family":"Waldo","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine","place":["Aurora, USA"]},{"name":"Rocky Mountain Regional VA Medical Center","place":["Aurora, USA"]},{"name":"VHA Office of Quality and Safety","place":["Washington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-4041","authenticated-orcid":false,"given":"Neel M.","family":"Butala","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine","place":["Aurora, USA"]},{"name":"Rocky Mountain Regional VA Medical Center","place":["Aurora, 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Meta\u2010analysis of individual patient data from the PROTECTED TAVR and BHF PROTECT\u2010TAVI trials. 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