{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:48:28Z","timestamp":1790927308682,"version":"4.1.0"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt\u2010sensitive hypertension, yet preclinical studies often focus on\u00a0men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">To examine sex\u2010specific responses to chronic salt loading, male and female C57Bl6\/J mice were fed a high\u2010salt diet (HSD; 8% NaCl) from 7 to 14\u2009months of age. Subsets of HSD mice were switched to a normal diet after 28\u2009weeks. Blood pressure was measured via tail\u2010cuff plethysmography, and cardiac function assessed by magnetic resonance imaging. Vascular responses were analyzed by wire myography, and histological and molecular analyses were performed on heart, aorta, and kidney tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After 56\u2009weeks, only HSD\u2010fed females exhibited increased systolic blood pressure (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.015), whereas HSD\u2010fed males showed elevated left ventricular stroke volume, end\u2010diastolic volume, and mass (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Males displayed aortic remodeling with increased wall thickness and synthetic smooth muscle marker expression. Mesenteric arteries had impaired contractile responses in males, whereas \u03b11\u2010adrenergic tone was elevated in HSD\u2010fed females. Despite no overt renal injury, renal vascular thickening was observed in HSD males and glomerulosclerosis in normal diet females. Diet reversal normalized blood pressure in females and reversed cardiac changes in males.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Chronic high salt intake leads to distinct sex\u2010specific cardiovascular remodeling in mice. Importantly, diet reversal mitigates these effects, highlighting the potential of dietary interventions in salt\u2010sensitive cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041945","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T09:14:47Z","timestamp":1760087687000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Sex\u2010Specific Cardiovascular Consequences of Long\u2010Term High\u2010Salt Diet in Mice"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-1574","authenticated-orcid":false,"given":"Jo\u00e3o M.N.","family":"Duarte","sequence":"first","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-1172","authenticated-orcid":false,"given":"Sevilay","family":"Sahoglu\u2010G\u00f6ktas","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Lund, Sweden"]},{"name":"University of Augsburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-1347","authenticated-orcid":false,"given":"Lotte","family":"Vanherle","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Lund, Sweden"]},{"name":"University of Augsburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Prakash","sequence":"additional","affiliation":[{"name":"University of Augsburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-2326","authenticated-orcid":false,"given":"Kerstin","family":"Stemmer","sequence":"additional","affiliation":[{"name":"University of Augsburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-5510","authenticated-orcid":false,"given":"Karl","family":"Sw\u00e4rd","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-5936","authenticated-orcid":false,"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Malm\u00f6, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Malm\u00f6, Sweden"]},{"name":"North\u2010West University","place":["Potchefstroom, South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-7213","authenticated-orcid":false,"given":"Anja","family":"Meissner","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Lund University","place":["Lund, Sweden"]},{"name":"University of Augsburg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"Guideline: Sodium Intake for Adults and Children","author":"World Health Organization","year":"2012","unstructured":"World Health Organization . 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