{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:13Z","timestamp":1787018113626,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Low serum albumin levels indicate frailty and are strong predictors of poor prognosis after mitral transcatheter edge\u2010to\u2010edge repair (M\u2010TEER); however, albumin levels are expected to improve in response to treatment for mitral regurgitation. No reports have elucidated the clinical effects of albumin changes after M\u2010TEER. Thus, we aimed to explore the association between early albumin changes and clinical outcomes after M\u2010TEER and to identify the associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Data from 2695 patients enrolled in a Japanese multicenter registry whose serum albumin levels were measured before and 1\u2009month after undergoing M\u2010TEER were retrospectively reviewed. Changes in albumin (\u0394\u2010albumin) were calculated and divided into 2 groups, namely improved albumin (\u0394\u2010albumin &gt;0) and worsening albumin (\u0394\u2010albumin \u22640) groups. The incidence, predictors, and clinical outcomes associated with early albumin changes were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After M\u2010TEER, albumin levels improved in 56.1% of the patients (n=1512). The independent predictors of worsening \u0394\u2010albumin comprised old age, acute procedure success not achieved, higher Clinical Frailty Scale, higher hemoglobin, impaired renal function, and preprocedural higher albumin levels (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Improved \u0394\u2010albumin was independently associated with reduced all\u2010cause mortality after M\u2010TEER (hazard ratio [HR], 0.62 [95% CI, 0.52\u20130.75],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Additionally, improved \u0394\u2010albumin was associated with a lower competing risk of heart failure hospitalization (HR, 0.78 [95% CI, 0.64\u20130.94],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Early improvement in \u0394\u2010albumin may serve as a measure of procedural benefits and a surrogate marker for predicting clinical outcomes after M\u2010TEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041961","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:04:28Z","timestamp":1752753868000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Impact of Early Changes in Serum Albumin on Patient Prognosis After Mitral\u2010Transcatheter Edge\u2010to\u2010Edge Repair"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8171-9268","authenticated-orcid":false,"given":"Kenichi","family":"Shibata","sequence":"first","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6382","authenticated-orcid":false,"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]},{"name":"Toyohashi Heart Center","place":["Toyohashi, Japan"]},{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-630X","authenticated-orcid":false,"given":"Ai","family":"Kagase","sequence":"additional","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-062X","authenticated-orcid":false,"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsunamoto","sequence":"additional","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Shimura","sequence":"additional","affiliation":[{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-2730","authenticated-orcid":false,"given":"Azusa","family":"Kurita","sequence":"additional","affiliation":[{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-7051","authenticated-orcid":false,"given":"Ryo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Toyohashi Heart Center","place":["Toyohashi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-109X","authenticated-orcid":false,"given":"Mike","family":"Saji","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]},{"name":"Toho University Faculty of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-5809","authenticated-orcid":false,"given":"Yuki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-033X","authenticated-orcid":false,"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[{"name":"Mitsui Memorial Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-1012","authenticated-orcid":false,"given":"Yusuke","family":"Enta","sequence":"additional","affiliation":[{"name":"Sendai Kosei Hospital","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-8205","authenticated-orcid":false,"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-1479","authenticated-orcid":false,"given":"Masaki","family":"Izumo","sequence":"additional","affiliation":[{"name":"St. Marianna University School of Medicine Hospital","place":["Kawasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Shonan Kamakura General Hospital","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5303","authenticated-orcid":false,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Teikyo University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-5129","authenticated-orcid":false,"given":"Makoto","family":"Amaki","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Suita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[{"name":"Saiseikai Kumamoto Hospital Cardiovascular Center","place":["Kumamoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-0978","authenticated-orcid":false,"given":"Junichi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Tokyo Woman\u2019s Medical University","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"New Tokyo Hospital","place":["Chiba, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Bota","sequence":"additional","affiliation":[{"name":"Sapporo Higashi Tokushukai Hospital","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-7613","authenticated-orcid":false,"given":"Yohei","family":"Ohno","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine","place":["Isehara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Saiseikai Yokohama City Eastern Hospital","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-1836","authenticated-orcid":false,"given":"Daisuke","family":"Hachinohe","sequence":"additional","affiliation":[{"name":"Sapporo Heart Center, Sapporo Cardio Vascular Clinic","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-2511","authenticated-orcid":false,"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Toyama University Hospital","place":["Toyama, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-1342","authenticated-orcid":false,"given":"Gaku","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Kinki University Faculty of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7994-7594","authenticated-orcid":false,"given":"Toshiaki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Nippon Medical School","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-7843","authenticated-orcid":false,"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[{"name":"Kurashiki Central Hospital","place":["Kurashiki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-1982","authenticated-orcid":false,"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"OCEAN\u2010Mitral 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of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.041961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T12:11:56Z","timestamp":1756296716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.041961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":20,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,8,5]]}},"alternative-id":["10.1161\/JAHA.125.041961"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.041961","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,5]]},"assertion":[{"value":"2025-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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