{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:21:35Z","timestamp":1781889695525,"version":"3.54.5"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with hypertension face a significantly elevated risk of renal dysfunction. However, whether this risk can be mitigated by joint risk factor control remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using Cox proportional hazards models, this study investigated the association between the number of controlled baseline risk factors (systolic blood pressure, low\u2010density lipoprotein cholesterol, fasting blood glucose, and body mass index) and the development and progression of chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed 77\u2009356 participants with hypertension and 1:1 age\u2010 and sex\u2010matched counterparts without hypertension for incident chronic kidney disease over a median follow\u2010up of 13.40\u2009years. Among participants with hypertension, each additional controlled risk factor was associated with an 18% lower risk of chronic kidney disease (hazard ratio [HR], 0.82 [95% CI, 0.81\u20130.84]), and controlling all 4 factors (versus \u22641) reduced the risk by 42% (HR, 0.58 [95% CI, 0.52\u20130.63]). Effective multifactorial management progressively narrowed the risk gap between hypertensive and normotensive individuals. Chronic kidney disease progression was assessed in 9543 participants with hypertension and 6799 participants without hypertension over 11.88\u2009years. Each additional controlled risk factor was associated with an 18% lower progression risk (HR, 0.82 [95% CI, 0.78\u20130.86]). Controlling 3 factors was sufficient to eliminate the excess progression risk between groups with hypertension and groups without hypertension, while controlling all 4 factors lowered the risk by 31% (HR, 0.69 [95% CI, 0.53\u20130.89]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study demonstrates a clear dose\u2013response relationship between the number of controlled risk factors and the magnitude of kidney risk reduction. A comprehensive, multifactorial control strategy can progressively reduce and potentially normalize the excess kidney risk in hypertensive individuals. These findings support a more quantitative and stage\u2010specific approach to hypertension management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.041962","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:06:37Z","timestamp":1764763597000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Multiple Risk Factor Management on the Onset and Progression of Chronic Kidney Disease in Patients With Hypertension"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-2392","authenticated-orcid":false,"given":"Xinyi","family":"Peng","sequence":"first","affiliation":[{"name":"Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases","place":["Beijing, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, 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