{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:15:11Z","timestamp":1789431311429,"version":"build-2803163510"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiovascular disease (CVD) represents the most significant global burden among all diseases. High systolic blood pressure (HBP) is the most prevalent risk factor for CVD. This study aims to investigate the global burden of CVDs attributable to high systolic blood pressure (HBP\u2010CVD) and to assess the effectiveness of disease control across different age groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">The burden was assessed by analyzing the numbers, age\u2010standardized rates of deaths, and disability\u2010adjusted life\u2010years, alongside the corresponding estimated annual percentage change, stratified by age, sex, sociodemographic index, and geographical regions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">From 1990 to 2021, the age\u2010standardized rates of death and disability\u2010adjusted life\u2010years declined, with estimated annual percentage changes of \u22121.45 and \u22121.36, respectively. However, owing to the growth in population, the current burden of HBP\u2010CVD is increasing. The age\u2010period\u2010cohort model suggests that the alleviation of disease burden is more pronounced in populations \u226550\u2009years of age, with the lowest point occurring around 70\u2009years of age. The age\u2010stratified estimated annual percentage change further substantiates this issue, revealing that disease control efforts are least effective in the 15 to 49\u2009years of age group, compared with the 50 to 69 and 70+ years of age groups. Overall, health inequities in HBP\u2010CVD are decreasing, yet they persist. More importantly, health inequities in the 15 to 49\u2009years of age group have exacerbated from 1990 to 2021.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The burden of HBP\u2010CVD remains severe, and disease control was least effective in the 15 to 49\u2009years of age group compared with the 50 to 69 and 70+ years of age groups. Urgent adjustments to health care policies are imperative.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.041964","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:18:02Z","timestamp":1749626282000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Cardiovascular Disease Attributable to High Systolic Blood Pressure in Younger Adults Requires Greater Attention: Insights from the Global Burden of Disease Study 2021"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-8406","authenticated-orcid":false,"given":"Fanqi","family":"Li","sequence":"first","affiliation":[{"name":"The Second Xiangya Hospital of Central South University","place":["Changsha, 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