{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:09:08Z","timestamp":1784113748889,"version":"3.55.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Atrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM) and increases stroke risk, primarily due to thromboembolism from the left atrial appendage (LAA). Oral anticoagulation (OAC) is recommended, but data on LAA thrombus (LAAT) in HCM and AF are limited. The current study aimed to assess LAAT prevalence in patients with HCM and AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed 170 patients with HCM and AF (mean age, 67.7\u00b112.4\u2009years; 57.1% men) who underwent at least one transesophageal echocardiogram (TEE) during a median follow\u2010up of 41.5 months (interquartile range, 15\u201377 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      At the time of TEE, 147 (86.5%) patients were undergoing OAC, with 52 (30.6%) taking vitamin K antagonists and 95 (55.9%) taking non\u2013vitamin K antagonist oral anticoagulants. LAAT was found in 36 patients (21.2%), with prevalence rates of 23.1% (n=12) in vitamin K antagonist users, 16.8% (n=16) in non\u2013vitamin K antagonist oral anticoagulant users, and 34.8% (n=8) in those without OAC. Non\u2013vitamin K antagonist oral anticoagulant use was associated with a significant LAAT risk reduction compared with no OAC (odds ratio, 0.20 [95% CI, 0.05\u20130.73];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02). Decreased LAA flow velocity (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) was independently linked to LAAT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">LAAT is common in patients with HCM and AF, even among those receiving OAC. Reduced LAA flow velocity may increase thrombus risk. TEE should be considered before rhythm\u2010control strategies, even in patients with HCM receiving anticoagulation, to minimize thromboembolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042010","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:09:31Z","timestamp":1769767771000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Left Atrial Appendage Thrombus in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation: Prevalence and Risk Factors"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-5716","authenticated-orcid":false,"given":"Leon","family":"Dinshaw","sequence":"first","affiliation":[{"name":"University Medical Center Hamburg\u2010Eppendorf","place":["Hamburg, Germany"]},{"name":"Sana Hanse Hospital Wismar","place":["Wismar, 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