{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:14:47Z","timestamp":1792613687017,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Neurodevelopmental outcomes are impaired in significant congenital heart disease (CHD) with prenatal origins. The cerebrovascular response to maternal hyperoxia (MH) varies in fetuses with CHD, which may reflect brain health in utero. We investigated the association between lack of cerebrovascular reactivity with MH and adverse neurologic outcomes in CHD measured as brain growth and risk of postnatal white matter injury.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This is a prospective cohort study of pregnant participants whose fetuses had CHD requiring a neonatal operation. We performed fetal echocardiograms with MH, fetal brain magnetic resonance imaging (MRI), and postnatal preoperative brain MRI. A \u22655% change in middle cerebral artery pulsatility index with MH defined reactivity. Total brain volume was measured on MRIs. The neonatal MRI was assessed for white matter injury. Regression analyses compared responders versus nonresponders, then stratified by hypoplastic left heart syndrome and d\u2010transposition of the great arteries groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Fifty\u2010five participants underwent fetal imaging. Forty\u2010nine neonates underwent brain MRI. Among subjects with hypoplastic left heart syndrome, at each gestational week, total brain volume was 17.8\u2009mL greater in responders (95% CI, 3.3\u201332.3;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.02). This pattern was not seen in d\u2010transposition of the great arteries. Postnatal white matter injury was less common in responders.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Lack of fetal cerebrovascular response to MH is associated with smaller total brain volume beginning in utero in hypoplastic left heart syndrome. Postnatal white matter injury is more common among nonresponders. MH testing can help identify individual fetuses with CHD at highest risk for adverse neurologic outcomes, particularly those with hypoplastic left heart syndrome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.042014","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:03:07Z","timestamp":1752753787000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Fetal Cerebrovascular Response to Maternal Hyperoxia Testing and Association With Brain Growth and Postnatal Brain Injury in Congenital Heart Disease"],"prefix":"10.1161","volume":"14","author":[{"given":"Mariam","family":"Taleb","sequence":"first","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-2230","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Xu","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yii","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-693X","authenticated-orcid":false,"given":"Anita J.","family":"Moon\u2010Grady","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-364X","authenticated-orcid":false,"given":"Patrick S.","family":"McQuillen","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-544X","authenticated-orcid":false,"given":"Shabnam","family":"Peyvandi","sequence":"additional","affiliation":[{"name":"University of California San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.11.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs281"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25940"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056305"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.09.096"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.08.022"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.068"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13747"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15852"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.3.257"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22024"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2013.32.6.1067"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6115"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29097"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21992"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","unstructured":"Uus AU Kyriakopoulou V Makropoulos A Fukami\u2010Gartner A Cromb D Davidson A Cordero\u2010Grande L Price AN Grigorescu I Williams LZJ et\u00a0al. 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