{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:45:30Z","timestamp":1793090730518,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Atrial fibrillation (AF) and mitral regurgitation (MR) are closely linked, and one may worsen the other. We investigated the impact of baseline AF in patients with MR undergoing transcatheter edge\u2010to\u2010edge repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">One\u2010hundred\u2010fifty\u2010six consecutive patients with symptomatic heart failure (HF) undergoing mitral valve transcatheter edge\u2010to\u2010edge repair for severe MR were studied. The primary end point was the composite outcome of death or HF hospitalization. Transthoracic echocardiograms were performed at baseline and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Mean age was 80.8\u00b18.8\u2009years and 82 (52.6%) patients were female. MR cause was primary in 69 (44.2%) and secondary in 87 (55.8%) patients. AF or atrial flutter was present in 59 (37.8%) patients at baseline. Mitral valve transcatheter edge\u2010to\u2010edge repair was successful (\u22642+ MR) in 58 (98.3%) and 94 (96.9%) patients with and without AF respectively (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.59). During median 12.5 months follow\u2010up, the primary end point occurred in 64 patients (2\u2010year Kaplan\u2013Meier estimated rate 41.0%), including death in 16 patients (10.3%) and HF hospitalization in 57 patients (36.5%). Baseline AF remained a significant independent predictor of death or HF hospitalization (adjusted hazard ratio, 2.03 [95% CI, 1.12\u20133.69],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02). Left ventricular end\u2010diastolic volume, left atrial volume, and right ventricular systolic pressure decreased during follow\u2010up among patients in sinus rhythm but not among those in AF. AF was associated with an increased risk of severe MR recurrence (18.6% versus 8.2%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with HF and severe MR treated with Mitral valve transcatheter edge\u2010to\u2010edge repair, baseline AF was associated with impaired right and left heart remodeling, more frequent MR recurrence, and more than doubling of the 2\u2010year risk of death or HF hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042016","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:06:41Z","timestamp":1752754001000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Atrial Fibrillation in Patients With Severe Mitral Regurgitation Undergoing Transcatheter Edge\u2010to\u2010Edge Repair"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-1869","authenticated-orcid":false,"given":"Carlo","family":"Mannina","sequence":"first","affiliation":[{"name":"Division of Cardiology","place":["New York, USA"]},{"name":"Mount Sinai Morningside, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]},{"name":"University of Palermo","place":["Palermo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-7155","authenticated-orcid":false,"given":"Akarsh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-4814","authenticated-orcid":false,"given":"Yash","family":"Prakash","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-7010","authenticated-orcid":false,"given":"Andreina","family":"Carbone","sequence":"additional","affiliation":[{"name":"University Hospital \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-9950","authenticated-orcid":false,"given":"Eduardo","family":"Bossone","sequence":"additional","affiliation":[{"name":"Federico II University","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-7318","authenticated-orcid":false,"given":"Antonino","family":"Tuttolomondo","sequence":"additional","affiliation":[{"name":"University of Palermo","place":["Palermo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-2668","authenticated-orcid":false,"given":"Edgar","family":"Argulian","sequence":"additional","affiliation":[{"name":"Division of Cardiology","place":["New York, USA"]},{"name":"Mount Sinai Morningside, Icahn School of Medicine at Mount Sinai","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-5934","authenticated-orcid":false,"given":"Sahil","family":"Khera","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-7346","authenticated-orcid":false,"given":"Parasuram","family":"Melarcode\u2010Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-8049","authenticated-orcid":false,"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-5471","authenticated-orcid":false,"given":"Jonathan","family":"Halperin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7219-990X","authenticated-orcid":false,"given":"Gilbert H. 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