{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:57:09Z","timestamp":1792515429384,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Accumulating evidence indicates that degenerative valvular heart disease (VHD) and rheumatoid arthritis (RA) share overlapping risk factors and intersecting inflammatory processes; however, their interrelationship remains insufficiently explored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Among 492\u2009745 UK Biobank participants without VHD at baseline, Cox proportional hazards models were conducted to assess the association between prevalent RA and new\u2010onset degenerative VHD, with sequential adjustments for demographic factors, lifestyle variables, and comorbidities. The end points of degenerative VHD in this study included 8 subtypes: aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, tricuspid stenosis, tricuspid regurgitation, pulmonary stenosis, and pulmonary regurgitation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among participants with RA (n=6673), 359 cases of degenerative VHD were recorded over a median follow\u2010up of 13.71 (interquartile range, 12.71\u201314.55) years, compared with 13\u2009518 cases in those without RA (n=486\u2009072) over a median follow\u2010up of 13.78 (interquartile range, 12.96\u201314.51) years. After full adjustment, RA was significantly associated with a higher risk of 3 types of new\u2010onset degenerative VHD: aortic stenosis (hazard ratio [HR], 1.64 [95% CI, 1.40\u20131.92]), aortic regurgitation (HR, 1.69 [95% CI, 1.34\u20132.13]), and mitral regurgitation (HR, 1.54 [95% CI, 1.32\u20131.81]), while no significant association was observed between RA and other degenerative VHD subtypes. Moreover, sex subgroup analyses revealed an interaction between sex and RA in the occurrence of aortic stenosis (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              for interaction=0.02) and mitral regurgitation (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              for interaction=0.04), indicating a higher risk in women.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The presence of RA indicated an elevated risk of new\u2010onset degenerative aortic stenosis, aortic regurgitation, and mitral regurgitation, which required further investigation and better disease management.<\/jats:p>\n          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