{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:24:09Z","timestamp":1793139849086,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"\n Background<\/jats:title>\n A typical hypertensive heart disease phenotype is the left ventricular hypertrophy (LVH) and dysfunction, measurable via LV mass and global longitudinal strain. We aimed to evaluate the LV mass\u2010to\u2010strain ratio (LV\u2010MSR) as a marker of the clinical course in patients with hypertensive heart disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively analyzed consecutive patients who underwent echocardiography at the time of hypertension diagnosis and at 6\u2010 to 18\u2010month intervals in tertiary centers from 2006 to 2021. Associations of LV\u2010MSR with LVH changes and clinical outcomes (cardiovascular death and heart failure hospitalization occurring after the second echocardiogram) were assessed using time\u2010dependent receiver\u2010operating characteristic analysis and multivariable Cox regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1600 patients (mean age 65.1\u2009years; 61.1% male), 23.4% had concentric LVH, and 21.5% had eccentric LVH at baseline. The median interval between echocardiograms was 10.2\u2009months (interquartile range, 6.8\u201313.4). LV\u2010MSR showed the highest discriminatory value for LVH changes (area under the curve, 0.726 [95% CI, 0.685\u20130.760]), outperforming LV mass index (area under the curve, 0.690 [95% CI 0.648\u20130.728];\n P<\/jats:italic>\n <0.001) and LV\u2010global longitudinal strain (area under the curve, 0.600 [95% CI 0.558\u20130.647];\n P<\/jats:italic>\n <0.001). Higher LV\u2010MSR was significantly associated with new\u2010onset LVH (global test\n P<\/jats:italic>\n <0.001) and persistent LVH (global test\n P<\/jats:italic>\n <0.001). LV\u2010MSR was an independent prognosticator, both as a continuous (adjusted hazard ratio [HR], 1.044 per +1\u2009g\/m\n 2<\/jats:sup>\n per % [95% CI 1.020\u20131.069]) or categorical variable (adjusted HR 2.267 for LV\u2010MSR, \u22656.52\u2009g\/m\n 2<\/jats:sup>\n per % [95% CI 1.520\u20133.381]). These associations remained consistent across subgroups by sex and baseline LVH status.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n LV\u2010MSR independently predicts LVH changes and clinical outcomes in hypertensive heart disease, serving as a superior prognostic marker compared with LV mass index or LV\u2010global longitudinal strain alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.042032","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:18:51Z","timestamp":1758280731000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Left Ventricular Mass\u2010to\u2010Strain Ratio to Predict Change in Left Ventricular Hypertrophy and Prognosis in Hypertensive Heart Disease"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-3924","authenticated-orcid":false,"given":"In\u2010Chang","family":"Hwang","sequence":"first","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, South Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-6690","authenticated-orcid":false,"given":"Hyue Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Chung\u2010Ang University Hospital","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-7106","authenticated-orcid":false,"given":"Jiesuck","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-2486","authenticated-orcid":false,"given":"Hong\u2010Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, South Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-9889","authenticated-orcid":false,"given":"Yeonyee E.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, South Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7067-5535","authenticated-orcid":false,"given":"Goo\u2010Yeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, South Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, South 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