{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:55Z","timestamp":1785250975404,"version":"3.55.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although large studies and pooled analyses of individual patient data have demonstrated the safety of deferring coronary revascularization based on a nonischemic intracoronary pressure index result, conflicting findings have emerged in specific patient subsets and with varying follow\u2010up. Thus, we conducted an updated comprehensive systematic review and meta\u2010analysis to investigate the cardiovascular outcomes associated with deferred or performed coronary revascularization based on intracoronary physiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Available studies were identified through a systematic search of PubMed, EMBASE, and CENTRAL. Efficacy outcomes investigated were major adverse cardiovascular events, all\u2010cause death, cardiovascular death, noncardiovascular death, myocardial infarction, and unplanned revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 24 studies enrolling 24\u2009285 patients were included in the meta\u2010analysis. After a mean\u00b1SD follow\u2010up of 2.6\u00b11.6\u2009years, patients undergoing physiology\u2010guided deferred revascularization show consistently better outcomes than patients who underwent revascularization, including all\u2010cause death (incidence rate ratio [IRR], 1.14 [95% CI, 1.00\u20131.30];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.05), cardiovascular death (IRR, 1.53 [95% CI, 1.17\u20132.00];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.002), and unplanned revascularization (IRR, 1.38 [95% CI, 1.06\u20131.79];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01). For major adverse cardiovascular events (IRR, 1.15 [95% CI, 0.99\u20131.34];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.07) and myocardial infarction (IRR, 1.24 [95% CI, 0.95\u20131.61];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.11), the associations did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients in whom revascularization was deferred based on intracoronary physiology show lower risk of adverse cardiovascular events compared with those who underwent revascularization. These findings suggest that pressure wire assessment has prognostic implications besides the indication for revascularization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042044","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:41:19Z","timestamp":1776850879000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Outcomes in Patients With Deferred and Performed Coronary Revascularization Based on Intracoronary Physiology: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-2859","authenticated-orcid":false,"given":"Marco","family":"Lombardi","sequence":"first","affiliation":[{"name":"Complutense University of Madrid","place":["Madrid, Spain"]},{"name":"University of Genova","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-2592","authenticated-orcid":false,"given":"Alejandro","family":"Travieso","sequence":"additional","affiliation":[{"name":"Complutense University of Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7534","authenticated-orcid":false,"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"San Luigi Gonzaga University Hospital, Orbassano, Rivoli Infermi Hospital, Rivoli","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-9801","authenticated-orcid":false,"given":"Moman A.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-7927","authenticated-orcid":false,"given":"Matthias","family":"G\u00f6tberg","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Davies","sequence":"additional","affiliation":[{"name":"Imperial College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-0112","authenticated-orcid":false,"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Complutense University of Madrid","place":["Madrid, 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