{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:30:43Z","timestamp":1789126243228,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This retrospective observational study compared adverse events (AEs) and health care resource use among patients with atrial fibrillation treated with dronedarone versus amiodarone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Adults with atrial fibrillation who initiated dronedarone or amiodarone between January 1, 2010 and September 30, 2021 were propensity score matched in Optum\u2019s deidentified Clinformatics Data Mart Database. Outcomes included AEs (described in the dronedarone\/amiodarone Food and Drug Administration labels and reported in the Food and Drug Administration AE Reporting System) and all\u2010cause and cardiovascular\u2010related health care resource use. Generalized linear models with Poisson distribution were used to compare the risk of AEs between the 2 cohorts. After matching, 12\u2009210 dronedarone\u2010treated patients were paired 1:1 with amiodarone\u2010treated patients. For each AE, patients who experienced the AE during baseline were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">During follow\u2010up, lower event rates of AEs were observed with dronedarone versus amiodarone; the rate ratio for any cardiac and vascular AE was 0.71 (95% CI, 0.69\u20130.72), any respiratory AE was 0.65 (95% CI, 0.63\u20130.66), and any gastrointestinal\/hepatobiliary AE was 0.81 (95% CI, 0.79\u20130.84). Compared with amiodarone\u2010treated patients, dronedarone\u2010treated patients experienced lower event rates of all\u2010cause hospitalization (0.69 [95% CI, 0.67\u20130.71]) and all\u2010cause outpatient visits (0.87 [95% CI, 0.87\u20130.87]). Although the incidence of cardiovascular\u2010related hospitalization was higher with dronedarone versus amiodarone, event rates were not statistically different. Cardiovascular\u2010related outpatient visits were significantly reduced with dronedarone versus amiodarone with an event rate of 0.95 (95% CI, 0.94\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this study, lower event\/incidence rates of AEs and health care resource use were observed in patients with atrial fibrillation treated with dronedarone versus amiodarone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042178","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T04:14:32Z","timestamp":1766117672000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Economic Outcomes of Dronedarone Versus Amiodarone Among Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4729-7820","authenticated-orcid":false,"given":"Benjamin A.","family":"Steinberg","sequence":"first","affiliation":[{"name":"Denver Health Medical Center","place":["Denver, USA"]},{"name":"University of Colorado Anschutz Medical Campus","place":["Aurora, USA"]},{"name":"University of Utah","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-3045","authenticated-orcid":false,"given":"Firas","family":"Dabbous","sequence":"additional","affiliation":[{"name":"Evidera","place":["Bethesda, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-041X","authenticated-orcid":false,"given":"Ron","family":"Preblick","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Shridharmurthy","sequence":"additional","affiliation":[{"name":"Evidera","place":["Bethesda, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-6814","authenticated-orcid":false,"given":"David S.","family":"McKindley","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6946-5031","authenticated-orcid":false,"given":"Jason","family":"Rashkin","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7633-2293","authenticated-orcid":false,"given":"Samuel","family":"Huse","sequence":"additional","affiliation":[{"name":"Evidera","place":["Bethesda, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Colby","sequence":"additional","affiliation":[{"name":"Evidera","place":["Bethesda, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-529X","authenticated-orcid":false,"given":"Jagmeet P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Mass General Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"257","article-title":"Atrial fibrillation: the most common arrhythmia","volume":"27","author":"Wyndham CR","year":"2000","unstructured":"Wyndham CR. 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