{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:00:02Z","timestamp":1792000802493,"version":"4.4.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Limited data exist on right ventricular (RV) function in lung disease\/hypoxia\u2010associated pulmonary hypertension (PH). We aimed to clarify the presence, characteristics, and clinical significance of RV dysfunction in patients with lung disease\/hypoxia\u2010associated PH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed data from 3 groups of patients: those with lung disease\/hypoxia\u2010associated PH, those without PH, and those with pulmonary arterial hypertension (PAH). RV volume was assessed using cardiac magnetic resonance imaging, and RV pressure data were obtained by right heart catheterization and analyzed using dedicated software and a single\u2010beat method. We then evaluated RV contractility by end\u2010systolic elastance (Ees), diastolic function by \u03b2 and end\u2010diastolic elastance, and RV\u2010pulmonary artery coupling by Ees\/arterial elastance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We studied 68 patients with lung disease\/hypoxia\u2010associated PH, 40 without PH, and 93 with PAH. In the lung disease\/hypoxia\u2010associated PH group, Ees was sustained (0.46 [95% CI, 0.26\u20130.75] mm\u2009Hg\/mL), whereas \u03b2 (0.035 [95% CI, 0.022\u20130.049]) and end\u2010diastolic elastance (0.19 [95% CI, 0.11\u20130.38] mm\u2009Hg\/mL) were higher, and Ees\/arterial elastance was lower (0.59 [95% CI, 0.27\u20130.79]) compared with the no\u2010PH group. There were no differences in these values between the groups with lung disease\/hypoxia\u2010associated PH and PAH. Ees\/arterial elastance was significantly correlated with the 6\u2010minute walk distance and associated with mortality (hazard ratio, 0.18 [95% CI, 0.04\u20130.79]) in the group with PAH, but it was not in the group with lung disease\/hypoxia\u2010associated PH. Similarly, whereas the group with PAH showed improvement in \u03b2 and Ees\/arterial elastance with pulmonary vasodilator therapy, such improvement was not observed in the group with lung disease\/hypoxia\u2010associated PH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In lung disease\/hypoxia\u2010associated PH, RV contractility is preserved, whereas diastolic function and RV\u2010pulmonary artery coupling are impaired. Further investigation is needed to elucidate the distinct clinical relevance of RV dysfunction in lung disease\/hypoxia\u2010associated PH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.042186","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:27:46Z","timestamp":1754998066000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Right Ventricular Dysfunction in Lung Disease\/Hypoxia\u2010Associated Pulmonary Hypertension"],"prefix":"10.1161","volume":"14","author":[{"given":"Hideki","family":"Shima","sequence":"first","affiliation":[{"name":"Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-9572","authenticated-orcid":false,"given":"Ichizo","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Hokkaido University","place":["Sapporo, 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