{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:36:02Z","timestamp":1792067762139,"version":"4.4.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Persistent low\u2010grade inflammation contributes to coronary artery disease (CAD), but how acute vigorous exercise and structured training affect systemic inflammatory biomarkers in stable CAD remains unclear. We evaluated the acute response to a single vigorous bout and the effects of a 12\u2010week high\u2010intensity interval training program on systemic inflammation in patients with stable CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In 168 patients with stable CAD, blood samples were collected before, immediately after, and 2 hours after a maximal incremental cycling test. Participants were then randomized to 12\u2009weeks of high\u2010intensity interval training or standard care; 142 completed follow\u2010ups. High\u2010sensitivity CRP (C\u2010reactive protein), leukocytes, interleukin\u20102, interleukin\u20106, interleukin\u201010, interferon\u2010\u03b3, and tumor necrosis factor\u2010\u03b1 were measured at baseline, week 6, and week 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute exercise elevated CRP by 7.7% [95% CI, 5.5\u201310.0] and leukocytes by 50.5% [95% CI, 48.2\u201352.8]; CRP returned to baseline by 2 hours, whereas leukocytes remained elevated. Interferon\u2010\u03b3 increased by 13.1% [95% CI, 9.2\u201317.3] following exercise but fell below baseline after 2 hours. Tumor necrosis factor\u2010\u03b1 (12.9% [95% CI, 8.4\u201317.4]), interleukin\u20102 (22.8% [95% CI, 17.5\u201328.5]), and interleukin\u20106 (42.4% [95% CI, 36.5\u201348.5]) also increased following acute exercise and stayed elevated after 2 hours, while interleukin\u201010 decreased by 9.2% [95% CI, \u221214.1 to \u20134.0] and returned to baseline after 2 hours. Over 12\u2009weeks, high\u2010intensity interval training did not significantly alter these inflammatory markers compared with standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute strenuous exercise induces transient increases in inflammatory markers in stable CAD, which begin to resolve within 2 hours. In this optimally treated cohort, regular high\u2010intensity interval training did not produce a sustained anti\u2010inflammatory effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04268992.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042256","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:29:14Z","timestamp":1770125354000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Acute Exercise and 12\u2010Week High\u2010Intensity Interval Training on Inflammatory Biomarkers in Stable Coronary Artery Disease: A Randomized Controlled Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-8970","authenticated-orcid":false,"given":"Jacobina","family":"Kristiansen","sequence":"first","affiliation":[{"name":"National Hospital of the Faroe Islands","place":["T\u00f3rshavn, Faroe Islands"]},{"name":"Aarhus University Hospital","place":["Aarhus, Denmark"]},{"name":"Aarhus University Hospital","place":["Aarhus, Denmark"]},{"name":"Aarhus University","place":["Aarhus, Denmark"]},{"name":"University of the Faroe Islands","place":["T\u00f3rshavn, Faroe Islands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Dalby","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital","place":["Aarhus, Denmark"]},{"name":"Aarhus University","place":["Aarhus, 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