{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:20:24Z","timestamp":1782739224898,"version":"3.54.5"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hematoma expansion (HE) is a significant risk factor for poor prognosis in patients with intracerebral hemorrhage (ICH). Accurately predicting HE is crucial for determining optimal treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study enrolled 452 patients with ICH from 10 hospitals. To predict HE, 28 clinical variables available on patient arrival (including medical history, ICH location, and ICH volume) and 1142 radiomics features extracted from noncontrast computed tomography images of the ICH regions were used. Clinical variables and radiomics features were selected using gradient boosting and the least absolute shrinkage and selection operator. Three HE prediction models were built on clinical variables alone, radiomics features alone, and a third combining both. The models were compared using 5\u2010fold cross\u2010validation, and the mean area under the receiver operating characteristic curve was calculated for each. Additionally, the important features of HE prediction in the combined model were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The combined model demonstrated the highest performance for predicting HE with a 5\u2010fold mean area under the receiver operating characteristic curve of 0.77\u00b10.05, compared with 0.70\u00b10.06 for the clinical variables alone and 0.73\u00b10.04 for the radiomics features alone. Permutation feature importance analysis suggested that anticoagulant treatment was the most predictive of HE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">A predictive model for HE was developed using the medical history, clinical features available on the patient\u2019s arrival, imaging, and radiomics features extracted from computed tomography images. This prediction model will assist non\u2013stroke care specialists in making treatment decisions for ICH in emergency settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042387","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T10:21:03Z","timestamp":1767090063000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Clinically Applicable Machine Learning Approach to Predict Intracerebral Hematoma Expansion"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5053-8405","authenticated-orcid":false,"given":"Shogo","family":"Watanabe","sequence":"first","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-2760","authenticated-orcid":false,"given":"Nice","family":"Ren","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-2708","authenticated-orcid":false,"given":"Yukihiro","family":"Imaoka","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-8197","authenticated-orcid":false,"given":"Kento","family":"Morita","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]},{"name":"Mie University","place":["Tsu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-4114","authenticated-orcid":false,"given":"Syoji","family":"Kobashi","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]},{"name":"University of Hyogo","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1990-1485","authenticated-orcid":false,"given":"Nobutaka","family":"Mukae","sequence":"additional","affiliation":[{"name":"Kyushu University","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-9506","authenticated-orcid":false,"given":"Koichi","family":"Arimura","sequence":"additional","affiliation":[{"name":"Kyushu University","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-0949","authenticated-orcid":false,"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-220X","authenticated-orcid":false,"given":"Koji","family":"Iihara","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]},{"name":"National Cerebral and Cardiovascular Center Hospital","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"J\u2010ASPECT study collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182143317"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318260cbba"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346599"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015062"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5433"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30253-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.040"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9765-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2020.05.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.04.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00491"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211060029"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"Seymour SE Rava RA Swetz DJ Monteiro A Baig A Schultz K Snyder KV Waqas M Davies JM Levy EI et\u00a0al. 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