{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:40:57Z","timestamp":1792032057482,"version":"4.4.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hematoma expansion (HE) is a potential modifier of intracerebral hemorrhage (ICH) outcome, yet reducing HE does not necessarily improve prognosis. This may reflect the complex relationship between location, baseline volume, HE, and outcomes, where different locations have varying hematoma growth and differing impacts on prognosis. Prior HE studies have oversimplified location categorization into lobar and deep. Therefore, we aim to investigate how HE varies across more specific location categorization and examine their interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed 691 nonanticoagulated patients with spontaneous ICH from the University of Hong Kong ICH registry (2011\u20132022) and 3 regional hospitals (2020\u20132022). Locations were categorized into lobar, putamen\/external capsule, globus pallidus\/internal capsule, thalamus, cerebellum, and brainstem. HE was defined as a &gt;33% or &gt;6\u2009mL increase in intraparenchymal hematoma. The associations between location and volume with HE were assessed using multivariable logistic regression. Location\u2010specific volume cutoffs were defined with the receiver operating characteristic curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The HE rates and absolute volume growth differed significantly by location (both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The risk of HE also varied across locations (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.016), but only cerebellar ICH showed a significantly lower risk compared with lobar ICH (adjusted odds ratio, 0.313 [95% CI, 0.098\u20130.998]). Additionally, there was a significant interaction between baseline volume and location with HE (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      &lt;0.001). HE risk was significantly higher for baseline hematoma volume \u226527.2\u2009mL for lobar (aOR, 8.71 [95% CI 3.35\u201322.64]) and\u226536.2\u2009mL for putamen\/external capsule (adjusted odds ratio, 2.83 [95% CI, 1.53\u20135.25]), but not for other location\u2010specific volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The risk of HE and its association with baseline volume varied by ICH locations. These findings provide novel insight to guide patient selection for antiexpansion therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042399","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:45:16Z","timestamp":1768391116000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Location\u2010Specific Analysis of Hematoma Expansion in Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8277-4745","authenticated-orcid":false,"given":"Ryan Wui\u2010Hang","family":"Ho","sequence":"first","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-6127","authenticated-orcid":false,"given":"Ji\u2010Fu","family":"Cai","sequence":"additional","affiliation":[{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8412-7385","authenticated-orcid":false,"given":"Ching Hei","family":"So","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u2010Long","family":"Leung","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Wu","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Lui","sequence":"additional","affiliation":[{"name":"Ruttonjee Hospital","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Bing","family":"Xiao","sequence":"additional","affiliation":[{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Shuang","family":"Zeng","sequence":"additional","affiliation":[{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8720-9760","authenticated-orcid":false,"given":"Joshua","family":"Fok","sequence":"additional","affiliation":[{"name":"Yan Chai Hospital","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3009-3846","authenticated-orcid":false,"given":"Edwin Kin\u2010Keung","family":"Yip","sequence":"additional","affiliation":[{"name":"Ruttonjee Hospital","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-6258","authenticated-orcid":false,"given":"Bun","family":"Sheng","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-2418","authenticated-orcid":false,"given":"Kui Kai","family":"Lau","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-2958","authenticated-orcid":false,"given":"Kay Cheong","family":"Teo","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong SAR, China"]},{"name":"The University of Hong Kong\u2013Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"95","article-title":"Outcomes after first\u2010ever stroke","volume":"13","author":"Cheung CM","year":"2007","unstructured":"Cheung CM, Tsoi TH, Hon SFK, Au\u2010Yeung M, Shiu KL, Lee CN, Huang CY. 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