{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:06:55Z","timestamp":1787792815103,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The blood pressure response index (BPRI) is an easy, rapid, precise dose\u2013effect index to reflect the cardiovascular response of patients with septic shock. However, the relationship between BPRI and clinical outcomes in patients with cardiogenic shock (CS) has not been elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We extracted the clinical data of patients with CS admitted to the ICU from the MIMIC\u2010IV (v3.1) database and the eICU Collaborative Research Database (eICU\u2010CRD). The predictive ability for in\u2010hospital mortality was evaluated using the receiver operating characteristic curve. The relationship between BPRI and in\u2010hospital mortality was explored utilizing restricted cubic splines, segmented logistic regression, and subgroup analysis. A new prediction model for CS was established and assessed by receiver operating characteristic curves and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      There were 1456 and 386 patients in the MIMIC\u2010IV and eICU\u2010CRD cohorts, respectively. BPRI had a better area under the receiver operator characteristic curve for predicting in\u2010hospital mortality than sequential organ failure assessment (SOFA) score and BOS, MA2 risk score in both MIMIC\u2010IV and eICU\u2010CRD cohort. We found an L\u2010shaped association between BPRI and in\u2010hospital mortality (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for nonlinear &lt;0.001), with the cutoff values at 2.4 in both cohorts. The newly developed model utilizing BPRI demonstrated a good predictive ability for in\u2010hospital mortality among patients with CS (area under the curve=0.799).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">BPRI is a powerful predictor for in\u2010hospital mortality among patients with CS admitted to the ICU. The application of BPRI can help clinicians achieve early warning of mortality risk and early decision\u2010making, guide the use of vasoactive drugs, and assist the risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042408","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:17:37Z","timestamp":1756466257000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Blood Pressure Response Index and Mortality in Patients With Cardiogenic Shock: A Multicenter Retrospective Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Xiaodong","family":"You","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongman","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Mao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-6446","authenticated-orcid":false,"given":"Xufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, 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SS Baran DA Jentzer JC Hollenberg SM van Diepen S Basir MB Grines CL Diercks DB Hall S Kapur NK et\u00a0al. SCAI SHOCK stage classification expert consensus update: a review and incorporation of validation studies: this statement was endorsed by the American College of Cardiology (ACC) American College of Emergency Physicians (ACEP) American Heart Association (AHA) European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC) International Society for Heart and Lung Transplantation (ISHLT) Society of Critical Care Medicine (SCCM) and Society of Thoracic Surgeons (STS) in December 2021. 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