{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:27:26Z","timestamp":1792175246827,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our objective was to assess real\u2010world outcomes and health care use associated with commercial mavacamten use in patients with obstructive hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We used the Symphony Dataverse to study patients receiving mavacamten between May 25, 2022 and June 30, 2024. Safety outcomes were prespecified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included 2440 patients and 18\u2009494 mavacamten dispenses (63% women, median age 66\u2009years [interquartile range {IQR}, 55\u201373]). Patients were followed for a median of 3037.0\u2009days (IQR, 2808\u20133221) before mavacamten initiation and for 240\u2009days (IQR, 117\u2013407) on mavacamten. Atrial fibrillation or flutter (AF\/AFL) at baseline were present in 536 (22%) of patients, whereas new\u2010onset AF\/AFL requiring therapy occurred in 125 patients (5%) and new heart failure (HF) in 100 patients (4%). During follow\u2010up, 154 patients (6%) received new dispenses of loop diuretics, 102 (4%) oral anticoagulants, 78 (3%) amiodarone, 17 (0.7%) sotalol, and 6 (0.2%) dofetilide. There was a total of 306 patients (13%) with 428 acute care episodes (most common claims were HF (n=80, 26%), AF (n=74, 24%), and AFL (n=16, 5%)). Predictors of outcomes (new HF, new AF\/AFL, ventricular tachycardia, or transient ischemic attack\/stroke claim) were age at mavacamten start, obesity, transient ischemic attack\/stroke history, and residence in the Western versus Southern United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Over an 8\u2010month median follow\u2010up on mavacamten in patients with obstructive hypertrophic cardiomyopathy, new AF\/AFL and HF occurred in 5% and 4%, respectively. Further work is needed to better understand the expected incidence of AF\/AFL, HF, and other long\u2010term outcomes of mavacamten treatment in obstructive hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042488","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:22Z","timestamp":1761648442000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Characteristics and Outcomes of Mavacamten Use in 2440 Patients With Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"14","author":[{"given":"Ingy","family":"Mahana","sequence":"first","affiliation":[{"name":"Knight Cardiovascular Institute, OHSU","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica T.","family":"Mejia","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, 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