{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:16Z","timestamp":1787721676455,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">We evaluated associations between untreated mild hyperglycemia and hypertensive disorders of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this retrospective study at a US academic medical center practicing universal 2\u2010step gestational diabetes (GD) testing, we defined normal glucose tolerance as a normal screening 50\u2010g, 1\u2010hour glucose load test (&lt;140\u2009mg\/dL). If the glucose loading test was abnormal, a diagnostic 100\u2010g, 3\u2010hour oral glucose tolerance test was performed. We defined GD as \u22652 abnormal oral glucose tolerance test values (Carpenter\u2013Coustan criteria) and gestational glucose intolerance (GGI, untreated subclinical hyperglycemia) as 0 (GGI\u20100) or 1 (GGI\u20101) abnormal oral glucose tolerance test value. We divided GD into treated and untreated (given use of older diagnostic criteria in the study period). We examined associations between GGI or GD and hypertensive disorders of pregnancy (primary outcome) or its subtypes (gestational hypertension, preeclampsia) using generalized estimating equations with confounder adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 41\u2009484 pregnancies, 84% had normal glucose tolerance, 12% had GGI (GGI\u20100: 9.0%, GGI\u20101: 3.0%) and 3.5% had GD. There was greater risk of hypertensive disorders of pregnancy in GGI compared with normal glucose tolerance (adjusted odds ratio [aOR], 1.24 [95% CI, 1.11\u20131.38]). This was attributable to increased risk in GGI\u20101 (aOR, 1.53 [95% CI, 1.27\u20131.85]), similar to untreated GD (aOR, 1.76 [95% CI, 1.37\u20132.26]). The risk of gestational hypertension was increased in GGI\u20101 (aOR, 1.66 [95% CI, 1.30\u20132.12]) and untreated GD (aOR, 1.89 [95% CI, 1.36\u20132.63]) but not in treated GD (aOR, 0.84 [95% CI, 0.58\u20131.23). The risk of preeclampsia was similarly increased in GGI\u20101, treated GD, and untreated GD (aOR, 1.46\u20131.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mild untreated hyperglycemia in pregnancy is associated with hypertensive disorders of pregnancy; hyperglycemia treatment is associated with reduced gestational hypertension risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042541","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:34:48Z","timestamp":1782210888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Gestational Glucose Intolerance and the Risk of Hypertensive Disorders of Pregnancy"],"prefix":"10.1161","volume":"15","author":[{"given":"Jacqueline","family":"Maya","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]},{"name":"Massachusetts General Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-372X","authenticated-orcid":false,"given":"Kaitlyn E.","family":"James","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin C. 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