{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:06:18Z","timestamp":1781359578961,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Methamphetamine\u2010associated pulmonary arterial hypertension (Meth\u2010PAH) represents a growing subset of PAH. Relative to idiopathic PAH (iPAH), it is unknown whether patients with Meth\u2010PAH treated with continuous prostacyclin have similar outcomes and treatment response. The aims of this analysis are to evaluate survival, response to therapy, and right ventricle function in similarly treated patients with Meth\u2010PAH and iPAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A prospective protocolized cohort of 138 incident patients (64 Meth\u2010PAH, 74 iPAH) was followed longitudinally, with all patients being treatment\u2010na\u00efve at baseline. Hemodynamic assessments, cardiac imaging, and response to therapy were evaluated. A standardized therapeutic approach involving parenteral subcutaneous treprostinil was applied. Survival was analyzed using Kaplan\u2013Meier and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Both groups had similarly advanced PAH at presentation. Improvement in hemodynamics and reduction in European Respiratory Society risk scores were seen over the course of follow\u2010up in both groups. Twenty\u2010nine of 64 (45%) Meth\u2010PAH and 51\/74 (69%) of iPAH were initiated on parenteral prostacyclin. During treatment, only 4 patients (2 iPAH and 2 meth\u2010PAH) were taken off treprostinil because of safety concerns. Transplant\u2010free survival was 54\/64 (84.4%) for meth\u2010PAH over a mean follow\u2010up time of 46\u2009months and 54\/74 (72.9%) for iPAH over a mean follow\u2010up time of 67\u2009months. Additionally, continued methamphetamine use did not adversely affect disease progression or mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among Meth\u2010PAH patients treated with an aggressive parenteral prostacyclin strategy, there is not a large difference in mortality and treatment response to iPAH. Further research is warranted to explore the long\u2010term effects of methamphetamine use on PAH pathogenesis and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042673","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:57Z","timestamp":1761648477000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment Response and Survival in Methamphetamine\u2010Associated Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-7294","authenticated-orcid":false,"given":"Cole","family":"Uhland","sequence":"first","affiliation":[{"name":"University of Arizona","place":["Tucson"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Legacy Health System","place":["Portland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Insel","sequence":"additional","affiliation":[{"name":"University of Arizona","place":["Tucson"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Kubba","sequence":"additional","affiliation":[{"name":"University of Arizona","place":["Tucson"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-8304","authenticated-orcid":false,"given":"Franz P.","family":"Rischard","sequence":"additional","affiliation":[{"name":"University of Arizona","place":["Tucson"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Hedegaard H Bastian BA. 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